N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide

Base Information

• Chemical Name: N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide
• CAS No.: 796-42-9
• Molecular Formula: C17H13N3O2
• Molecular Weight: 291.309
• Hs Code.: 2933399090
• Mol file: 796-42-9.mol

Synonyms:Isonicotinsaeure-[(2-hydroxy-[1]naphthylmethylen)-hydrazid];1-Isonicotinoyl-5-(4-nitro-phenyl)-carbohydrazid;isonicotinic acid-[(2-hydroxy-[1]naphthylmethylene)-hydrazide];2-hydroxy-1-naphthyl aldehyde isonicotinoyl hydrazone;(E)-N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide;2-hydroxy-1-napthaldehyde isonicotinoylhydrazone;1-isonicotinyl-2-(2-hydroxy-1-naphthylidene) hydrazine;

Chemical Property of N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide

Chemical Property:

• Boiling Point: 503.5oC at 760 mmHg
• Flash Point: 258.3oC
• PSA: 74.58000
• Density: 1.364g/cm3
• LogP: 3.09520
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• Solubility.: Soluble in DMSO (45 mg/ml); ethanol (10 mg/ml with warming)

Purity/Quality:

99.3% ^*data from raw suppliers

AS8351 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: AS-8351 is a histone demethylase inhibitor. It has been used in combination with CHIR99021 , A 83-01 , BIX01294 , SC-1 , Y-27632 (Item No. 10005583), OAC2 , SU 16f , and JNJ-10198409 to induce reprogramming of human fetal lung fibroblasts into functional cardiomyocytes.
• Uses: AS 8351 is used in the conversion of human fibroblasts into functional cardiomyocytes, which provides a promising source for regenerative therapy.

Technology Process of N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide

There total 2 articles about N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

isoniazid (54-85-3,7640-37-1) + 2-hydroxynaphthalene-1-carbaldehyde (708-06-5) → (E)-N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide (796-42-9,329183-01-9)

Guidance literature:

In methanol; Reflux;

DOI:10.1002/ejic.201601359

Reference yield:

→ (E)-N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide (796-42-9,329183-01-9)

Guidance literature:

Beim Erwaermen von 2-Hydroxy-naphthalin-1-aldehyd mit 4-Hydrazino-carbonyl-pyridin in A.;

DOI:10.1248/yakushi1947.87.1_27

Reference yield: 66.4%

(E)-N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide (796-42-9,329183-01-9) + diphenyltin(IV) dichloride (1135-99-5) → C29H21N3O2Sn

Guidance literature:

With triethylamine; In methanol; for 3h; Reflux;

DOI:10.1016/j.poly.2014.04.061

upstream raw materials:

isoniazid

2-hydroxynaphthalene-1-carbaldehyde

Refernces

• 1、 Bhattacherjee, Prama,John, Rohith P.,Mitra, Partha,Sarkar, Prasenjit. "A three-dimensional manganese(II) coordination polymer: synthesis, structure and catecholase activity". . . Retrieved 2020/03/31.
• 2、 Sedaghat, Tahereh,Yousefi, Maryam,Bruno, Giuseppe,Amiri Rudbari, Hadi,Motamedi, Hossein,Nobakht, Valiollah. "Synthesis, spectral characterization, crystal structure and antibacterial studies of diorganotin(IV) complexes with isonicotinoyl hydrazone derivatives". . p. 88 - 96. Retrieved 2014/06/10.