Irinotecan

Base Information Edit

Chemical Name:Irinotecan
CAS No.:97682-44-5
Molecular Formula:C₃₃H₃₈N₄O₆
Molecular Weight:586.688
Hs Code.:
European Community (EC) Number:691-567-9
NSC Number:728073
UNII:7673326042
DSSTox Substance ID:DTXSID1041051
Nikkaji Number:J261.801J
Wikipedia:Irinotecan
Wikidata:Q412197
NCI Thesaurus Code:C62040
RXCUI:51499
Pharos Ligand ID:PZX523N3G85U
Metabolomics Workbench ID:43059
ChEMBL ID:CHEMBL481
Mol file:97682-44-5.mol

Synonyms:7 Ethyl 10 hydroxycamptothecin;7-ethyl-10-hydroxycamptothecin;Camptosar;Camptothecin 11;camptothecin-11;CPT 11;CPT-11;CPT11;irinotecan;irinotecan hydrochloride;Irrinotecan;NK012 compound;SN 38;SN 38 11;SN-38;SN-38-11;SN3811

Suppliers and Price of Irinotecan

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
CPT 11
10mg
$ 480.00

TRC
(+)-Irinotecan
50mg
$ 60.00

Tocris
CPT11 ≥99%(HPLC)
10
$ 229.00

Tocris
CPT11 ≥99%(HPLC)
50
$ 960.00

DC Chemicals
Irinotecan >98%
1 g
$ 500.00

CSNpharm
Irinotecan
100mg
$ 92.00

CSNpharm
Irinotecan
50mg
$ 61.00

Crysdot
Irinotecan 98+%
100mg
$ 125.00

Chemtos
IrinotecanLabeledd10
25 mg
$ 1400.00

ChemScene
Irinotecan 99.84%
50mg
$ 72.00

Total 174 raw suppliers

Chemical Property of Irinotecan Edit

Chemical Property:

Melting Point:222-223°
Boiling Point:873.4 °C at 760 mmHg
PKA:11.20±0.20(Predicted)
Flash Point:482 °C
PSA：114.20000
Density:1.4 g/cm³
LogP:3.96690
Storage Temp.:2-8°C
Solubility.:Acetonitrile (Slightly, Heated, Sonicated), DMSO (Slightly), Methanol (Slightly)
XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:5
Exact Mass:586.27913494
Heavy Atom Count:43
Complexity:1200

Purity/Quality:

99.0%, ^*data from raw suppliers

CPT 11 ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)C4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N7CCCCC7
Isomeric SMILES:CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)[C@@]4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N7CCCCC7
Recent ClinicalTrials:A Phase I Dose Finding Study in Children With Solid Tumors Recurrent or Refractory to Standard Therapy
Recent EU Clinical Trials:A Phase 1/2 Open-Label, Umbrella Platform Design Study of Investigational Agents With Pembrolizumab (MK-3475) in Participants With Advanced Esophageal Cancer Previously Exposed to PD-1/PD-L1 Treatment (KEYMARKER-U06): Substudy 06B.
Recent NIPH Clinical Trials:C-PROWESS study
Uses (+)-Irinotecan is a Topo I inhibitor. Irinotecan is a topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively

Technology Process of Irinotecan

There total 58 articles about Irinotecan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 103816-19-9
4-piperidinopiperidine-1-carbonyl chloride

: 86639-52-3,110714-48-2,130144-34-2,113015-38-6,647852-82-2
7-ethyl-10-hydroxycamptothecin

: 97682-44-5,130144-33-1
irinotecan

Guidance literature:: With pyridine; acetamide; triethylamine; In dichloromethane; at 30 - 40 ℃; for 2h; Product distribution / selectivity; Inert atmosphere;