Mestanolone

Base Information

• Chemical Name: Mestanolone
• CAS No.: 521-11-9
• Deprecated CAS: 119017-17-3,28801-95-8
• Molecular Formula: C20H32O2
• Molecular Weight: 304.473
• Hs Code.: 29372900
• European Community (EC) Number: 208-302-6
• NSC Number: 18219
• UNII: S712YZ168E
• DSSTox Substance ID: DTXSID0048973
• Nikkaji Number: J5.180B
• Wikipedia: Mestanolone
• Wikidata: Q1924446
• NCI Thesaurus Code: C83939
• Pharos Ligand ID: HRCZUNSUDK1Q
• Metabolomics Workbench ID: 35329
• ChEMBL ID: CHEMBL261514
• Mol file: 521-11-9.mol

Synonyms:5a-Androstan-3-one, 17b-hydroxy-17-methyl-(6CI,7CI,8CI);17a-Methyl-17b-hydroxy-5a-androstan-3-one;17a-Methyl-5a-androstan-17b-ol-3-one;17a-Methyl-5a-dihydrotestosterone;17a-Methylandrostan-17b-ol-3-one;17a-Methylandrostan-3-on-17b-ol;17a-Methylandrostanolone;17a-Methyldihydrotestosterone;17b-Hydroxy-17-methyl-5a-androstan-3-one;17b-Hydroxy-17a-methyl-3-androstanone;17b-Hydroxy-17a-methyl-5a-androstan-3-one;5a-Androstan-17a-methyl-17b-ol-3-one;Androstalone;Assimil;Mestalone;Mestanolon;Mestanolone;Methybol;Methylandrostanolone;Methylantalon;NSC 18219;Preroide;RU 143;Tantarone;

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Mestanolone

Chemical Property:

• Appearance/Colour: White Solid
• Vapor Pressure: 1.16E-08mmHg at 25°C
• Melting Point: 191 °C
• Refractive Index: 1.528
• Boiling Point: 416.1 °C at 760mmHg
• PKA: 15.15±0.60(Predicted)
• Flash Point: 177.6 °C
• PSA: 37.30000
• Density: 1.064 g/cm³
• LogP: 4.34920
• Storage Temp.: Controlled Substance, -20?C Freezer
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 304.240230259
• Heavy Atom Count: 22
• Complexity: 500

Purity/Quality:

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 40
• Safety Statements: 22-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC12CCC(=O)CC1CCC3C2CCC4(C3CCC4(C)O)C
• Isomeric SMILES: C[C@]12CCC(=O)C[C@@H]1CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@]4(C)O)C
• Description: Mestanolone is an orally active anabolic-androgenic steroid and the 17α-methylated derivative of dihydrotestosterone (DHT), which is an endogenous androgen sex steroid and hormone. It is capable of increasing testosterone benefit, suppressing estrogen effect, leaning muscle tissue, increasing strength as well as improving drive and focus. It is mainly used for the treatment of male hypogonadism and decreased sperm infertility.
• Uses: Anabolic steroid. Controlled substance.

Technology Process of Mestanolone

There total 21 articles about Mestanolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

ZIN(223)C05451 (641-82-7,641-84-9,4085-03-4,63088-07-3,63121-01-7,88729-24-2,88729-25-3,88729-26-4,88729-27-5,88980-24-9,103881-21-6,120925-80-6,641-83-8) → mestanolone (521-11-9,7241-35-2)

Guidance literature:

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dimethyl sulfoxide; at 65 ℃; for 2h;

DOI:10.1248/cpb.52.989

Reference yield: 82.8%

C22H36O2 → mestanolone (521-11-9,7241-35-2)

Guidance literature:

With toluene-4-sulfonic acid; In chloroform; at 50 - 55 ℃; Reagent/catalyst; Solvent;

Reference yield:

methylene chloride (74-87-3) + 3-ethoxyandrosta-3,5-dien-17-one (972-46-3) → mestanolone (521-11-9,7241-35-2)

Guidance literature:

methylene chloride; With iodine; magnesium; In tetrahydrofuran; at 40 - 45 ℃; for 1h;

3-ethoxyandrosta-3,5-dien-17-one; In tetrahydrofuran; at 10 - 45 ℃; for 12.08h; Further stages;

upstream raw materials:

17-methyl-5α-androstane-3α,17β-diol

ZIN⁽²²³⁾C₀₅₄₅₁

17-methyltestosterone

acetic acid

Downstream raw materials:

(5S,8R,9S,10S,13S,14S,17S)-17-Hydroxy-10,13,17-trimethyl-3-oxo-hexadecahydro-cyclopenta[a]phenanthrene-2-carboxylic acid

17-methyl-5α-androstane-3α,17β-diol

ZIN⁽²²³⁾C₀₅₄₅₁

Frazalon

Refernces

• 1、 -. "Preparation method of androstane-17alpha-methyl-17beta-hydroxy-3-ketone". Paragraph 0018; 0019. . Retrieved 2019/05/04.
• 2、 Gauthier, Julie,Poirier, Donald,Ayotte, Christiane. "Characterization of desoxymethyltestosterone main urinary metabolite produced from cultures of human fresh hepatocytes". experimental part. p. 635 - 643. Retrieved 2012/06/01.