Salicylhydroxamic acid

Base Information

• Chemical Name: Salicylhydroxamic acid
• CAS No.: 89-73-6
• Deprecated CAS: 72027-50-0
• Molecular Formula: C7H7 N O3
• Molecular Weight: 153.137
• Hs Code.: 29242990
• European Community (EC) Number: 201-934-3
• NSC Number: 193440,5088
• UNII: 8Q07182D0T
• DSSTox Substance ID: DTXSID5075365
• Nikkaji Number: J5.157H
• Wikipedia: Salicylhydroxamic_acid
• Wikidata: Q7404461
• Metabolomics Workbench ID: 67819
• ChEMBL ID: CHEMBL309339
• Mol file: 89-73-6.mol

Synonyms:salicylhydroxamate;salicylhydroxamic acid;SHAM

Chemical Property of Salicylhydroxamic acid

Chemical Property:

• Appearance/Colour: brownish crystalline powder
• Vapor Pressure: 9.01E-07mmHg at 25°C
• Melting Point: 175 - 178 C
• Refractive Index: 1.5500 (estimate)
• Boiling Point: 389.7°C at 760 mmHg
• PKA: pK (25°) 4.19
• Flash Point: 248.9oC
• PSA: 69.56000
• Density: 1.402g/cm3
• LogP: 0.90210
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility.: It is soluble in water.
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 153.042593085
• Heavy Atom Count: 11
• Complexity: 149

Purity/Quality:

98%,99%, ^*data from raw suppliers

Salicylhydroxamic acid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38-40
• Safety Statements: 22-26-36-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Nitrogen Compounds -> Other Aromatics (Nitrogen)
• Canonical SMILES: C1=CC=C(C(=C1)C(=O)NO)O
• Recent ClinicalTrials: Inhaled Nitric Oxide for Cardiac Arrest in Pediatrics and Adults (iNOCAPA)
• Uses: Salicylhydroxamic acid is a collector with efficient chelating effect on rare metal oxide minerals. It is used in rare metal beneficiation and has the advantages of good selectivity and strong collecting power. Salicylhydroxamic acid is mainly used as a complexing agent or extractant for rare earth ore, copper oxide ore, lead-zinc oxide ore, gold ore, kaolin, etc., as well as organic synthesis intermediates.

Technology Process of Salicylhydroxamic acid

There total 17 articles about Salicylhydroxamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl salicylate (119-36-8,8024-54-2) → salicylhydroxamic acid (89-73-6)

Guidance literature:

With sodium hydroxide; hydroxylamine; In 1,4-dioxane; water; at 20 ℃; for 12h;

Reference yield: 92.17%

salicylic acid (69-72-7,25496-36-0,8052-31-1) → salicylhydroxamic acid (89-73-6)

Guidance literature:

salicylic acid; With acetic anhydride; for 0.166667h;

With hydroxylamine hydrochloride; for 1h;

Reference yield: 83.0%

salicylaldehyde (90-02-8) → salicylhydroxamic acid (89-73-6)

Guidance literature:

With menadione; hydroxylamine hydrochloride; water; silver nitrate; triethylamine; In tetrahydrofuran; ethanol; at 20 ℃; for 0.5h; Irradiation; Green chemistry;

DOI:10.1007/s11164-018-3549-z

upstream raw materials:

piloty's acid

salicylaldehyde

salicyloyl chloride

methyl salicylate

Downstream raw materials:

5-bromo-N,2-dihydroxybenzamide

2-Benzoxazolinone

3.5-Dibrom-salicylhydroxamsaeure

3-Hydroxy-2H-1,3-benzoxazin-2,4(3H)-dion

Refernces

• 1、 -. "Method for synthesizing hydroximic acid compound". Paragraph 0083-0086. . Retrieved 2019/06/13.
• 2、 Li, Bo,Wu, Jun,Zhang, Wenxuan,Li, Zhongwen,Chen, Gang,Zhou, Qi,Wu, Song. "Synthesis and biological activity of salinomycin-hydroxamic acid conjugates". . p. 1624 - 1626. Retrieved 2017/03/16.