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azane;dichloroplatinum

Base Information Edit
  • Chemical Name:azane;dichloroplatinum
  • CAS No.:14913-33-8
  • Molecular Formula:Cl2H6N2Pt
  • Molecular Weight:300.047
  • Hs Code.:28439000
  • Wikidata:Q412415
  • Mol file:14913-33-8.mol
azane;dichloroplatinum

Synonyms:trans-DDP;trans-diamminedichloroplatinum II;trans-dichlorodiammineplatinum II;transplatin

Suppliers and Price of azane;dichloroplatinum
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • Transplatin
  • 10mg
  • $ 65.00
  • TRC
  • Transplatin
  • 250mg
  • $ 105.00
  • Strem Chemicals
  • trans-Dichlorodiammine platinum(II), 99%
  • 5g
  • $ 765.00
  • Strem Chemicals
  • trans-Dichlorodiammine platinum(II), 99%
  • 1g
  • $ 192.00
  • Sigma-Aldrich
  • Cisplatin impurity A European Pharmacopoeia (EP) Reference Standard
  • y0001018
  • $ 190.00
  • Sigma-Aldrich
  • trans-Platinum(II)diammine dichloride
  • 1g
  • $ 246.00
  • Sigma-Aldrich
  • trans-Platinum(II)diammine dichloride
  • 250mg
  • $ 88.10
  • Sigma-Aldrich
  • Transplatin United States Pharmacopeia (USP) Reference Standard
  • 25mg
  • $ 1260.00
  • Rare Earth Products
  • trans-Dichlorodiammineplatinum(II)
  • 5gm
  • $ 323.00
  • Medical Isotopes, Inc.
  • Transplatin
  • 100 mg
  • $ 2200.00
Total 63 raw suppliers
Chemical Property of azane;dichloroplatinum Edit
Chemical Property:
  • Appearance/Colour:Yellow Powder or Crystal 
  • Melting Point:340 °C (dec.)(lit.) 
  • PSA:6.48000 
  • Density:3.746 g/cm3 
  • LogP:2.02430 
  • Storage Temp.:2-8°C 
  • Water Solubility.:Soluble in dimethylsulfoxide and dimethylformamide. Slightly soluble in water. 
  • Hydrogen Bond Donor Count:2
  • Hydrogen Bond Acceptor Count:2
  • Rotatable Bond Count:0
  • Exact Mass:298.955598
  • Heavy Atom Count:5
  • Complexity:2.8
Purity/Quality:

99%, *data from raw suppliers

Transplatin *data from reagent suppliers

Safty Information:
  • Pictogram(s): ToxicT; HarmfulXn 
  • Hazard Codes:T,Xn 
  • Statements: 45-25-41-68-42/43-40-23/24/25 
  • Safety Statements: 53-26-39-45-36/37-24-23 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:N.N.Cl[Pt]Cl
  • Recent ClinicalTrials:Genetic Testing in Screening Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been or Will Be Removed by Surgery (The ALCHEMIST Screening Trial)
  • Recent EU Clinical Trials:A Global, Phase 3, Randomized, Multicenter, Open-Label Study to Investigate the Efficacy and Safety of Furmonertinib Compared to Platinum-Based Chemotherapy as First-Line Treatment for Patients with Locally Advanced or Metastatic Non-Small Cell Lung Cancer with Epidermal Growth Factor Receptor Exon 20 Insertion Mutations
  • Recent NIPH Clinical Trials:Phase 3 study of pembrolizumab vs chemotherapy in dMMR advanced or recurrent endometrial carcinoma
  • Uses Transplatin is the trans stereoisomer impurity of trans-Dichlorodiamineplatinum(II), an antineoplastic used in the treatment of sarcomas, some carcinomas, lymphomas, and germ cell tumors. Transplatin binds to DNA but does not exhibit the same useful pharmacological effect as its cis stereoisomer. Transplatin is the trans stereoisomer impurity of Cisplatin (C499500), an antineoplastic used in the treatment of sarcomas, some carcinomas, lymphomas, and germ cell tumors. Transplatin binds to DNA but does not exhibit the same useful pharmacological effect as its cis stereoisomer.
Technology Process of azane;dichloroplatinum

There total 115 articles about azane;dichloroplatinum which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
cis-diaminediiodoplatinum(II); With silver sulfate; In water; at 80 ℃;
potassium chloride; In water; at 80 ℃; for 0.333333h;
DOI:10.1021/jacs.9b10319
Guidance literature:
With sodium L-ascorbate; In tetrahydrofuran; aq. phosphate buffer; dimethyl sulfoxide; at 20 ℃; pH=7.4; Kinetics;
DOI:10.1002/cmdc.201800105
Guidance literature:
With sodium L-ascorbate; In aq. phosphate buffer; at 20 ℃; pH=7.4; Kinetics;
DOI:10.1002/cmdc.201800105
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