2-propylquinazolin-4(1H)-one

Base Information

• Chemical Name: 2-propylquinazolin-4(1H)-one
• CAS No.: 4765-54-2
• Molecular Formula: C11H12 N2 O
• Molecular Weight: 188.229
• Mol file: 4765-54-2.mol

Synonyms:4(1H)-Quinazolinone,2-propyl- (9CI); 2-Propyl-4(3H)-quinazolinone; 2-Propyl-4-quinazolinone; NSC155575

Chemical Property of 2-propylquinazolin-4(1H)-one

Chemical Property:

• Vapor Pressure: 0.000175mmHg at 25°C
• Boiling Point: 329.6°Cat760mmHg
• Flash Point: 153.2°C
• Density: 1.18g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-propylquinazolin-4(1H)-one

There total 15 articles about 2-propylquinazolin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

butyraldehyde (123-72-8) + anthranilic acid amide (28144-70-9,88-68-6) → 2-propyl-3H-quinazolin-4-one (4765-54-2)

Guidance literature:

With iodine; In ethanol; Reflux; Green chemistry;

DOI:10.1039/c5ra11262a

Reference yield: 95.0%

tributylamine N-oxide (7529-21-7) + anthranilic acid amide (28144-70-9,88-68-6) → 2-propyl-3H-quinazolin-4-one (4765-54-2)

Guidance literature:

With diphenyl-phosphinic acid; In 1,4-dioxane; at 130 ℃; for 10h; Inert atmosphere;

DOI:10.1039/c4ob00578c

Reference yield: 93.0%

triethyl orthobutyrate (24964-76-9) + anthranilic acid amide (28144-70-9,88-68-6) → 2-propyl-3H-quinazolin-4-one (4765-54-2)

Guidance literature:

With acetic acid; In ethanol; Reflux; Inert atmosphere;

DOI:10.3390/molecules23112925

upstream raw materials:

butyraldehyde

anthranilic acid amide

2-Iodobenzoic acid

butylamidine hydrochloride

Downstream raw materials:

N-[2-(1-Hydroxy-1-methyl-ethyl)-phenyl]-butyramide

2-(β-Ethylstyryl)-4(3H)-quinazolinone

N-[2-(Hydroxy-diphenyl-methyl)-phenyl]-butyramide

2-propyl-4-phenylquinazoline

Refernces

• 1、 Dang, Minh-Huy Dinh,Nguyen, Trang Thi Minh,Nguyen, Linh Ho Thuy,Nguyen, Trang Thi Thu,Phan, Thang Bach,Tran, Phuong Hoang,Doan, Tan Le Hoang. "Effect of Fe(iii)-based MOFs on the catalytic efficiency of the tandem cyclooxidative reaction between 2-aminobenzamide and alcohols". supporting information. p. 14529 - 14535. Retrieved 2020/10/02.
• 2、 Dai, Zeshu,Li, Dan,Li, Zhiyao,Liu, Heng,Luo, Wen,Shang, Suqin,Tian, Qingqiang,Wang, Shuqi,Wang, Xuetong,Wang, Yin,Wu, Huili,Xiao, Xin,Yuan, Jianyong,Zhou, Shangjun. "Imidazolium chloride as an additive for synthesis of 4(3H)-quinazolinones using anthranilamides and DMF derivatives". . . Retrieved 2020/09/10.