3-Bromo-1,1,2,2-tetrafluoropropane

Base Information

• Chemical Name: 3-Bromo-1,1,2,2-tetrafluoropropane
• CAS No.: 679-84-5
• Molecular Formula: C3H3 Br F4
• Molecular Weight: 194.954
• UNII: 3DC4A5894W
• DSSTox Substance ID: DTXSID40862366
• Nikkaji Number: J53.870A
• Wikipedia: Halopropane
• Wikidata: Q19597400
• Mol file: 679-84-5.mol

Synonyms:3-bromo-1,1,2,2-tetrafluoropropane;halopropane

Chemical Property of 3-Bromo-1,1,2,2-tetrafluoropropane

Chemical Property:

• Vapor Pressure: 116mmHg at 25°C
• Melting Point: 25°C
• Refractive Index: nD25 1.3558
• Boiling Point: 75.2°C at 760 mmHg
• PSA: 0.00000
• Density: 1.718g/cm³
• LogP: 2.28170
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 193.93543
• Heavy Atom Count: 8
• Complexity: 71.7

Purity/Quality:

99% ^*data from raw suppliers

3-bromo-1,1,2,2-tetrafluoropropane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C(C(F)F)(F)F)Br
• Uses: 3-bromo-1,1,2,2-tetrafluoropropane is a chemical reagent used in the preparation of pesticides as well as novel tyrosinase inhibitors.

Technology Process of 3-Bromo-1,1,2,2-tetrafluoropropane

There total 12 articles about 3-Bromo-1,1,2,2-tetrafluoropropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

p-toluenesulfonic acid-2,2,3,3-tetrafluoropropyl ester (786-31-2) → 1-bromo-2,2,3,3-tetrafluoropropnae (679-84-5)

Guidance literature:

With potassium bromide; In diethylene glycol; at 160 - 170 ℃;

DOI:10.1021/je00025a039

Reference yield: 87.0%

2,2,3,3-tetrafluoropropanol (76-37-9) → 1-bromo-2,2,3,3-tetrafluoropropnae (679-84-5)

Guidance literature:

With bromine; triphenylphosphine; In tetrachloromethane; Heating;

Reference yield: 71.0%

1,1,3-trihydroperfluoropropyl benzenesulfonate (65675-12-9) → 1-bromo-2,2,3,3-tetrafluoropropnae (679-84-5)

Guidance literature:

With alkali bromide (KBr or NaBr); In N,N-dimethyl-formamide; Heating;

upstream raw materials:

p-toluenesulfonic acid-2,2,3,3-tetrafluoropropyl ester

bromal

2-(2,2,3,3-tetrafluoropropoxy)-4,5-benzo-1,3,2-dioxaphospholane

bromocyane

Downstream raw materials:

benzyl 2,2,3,3-tetrafluoropropyl sulfide

2,3,3-trifluoroprop-1-ene

Refernces

• 1、 Yagupolskii, Yu. L.,Pavlenko,Shelyazhenko,Filatov,Kremlev,Mushta,Gerus,Peng, Sheng,Petrov,Nappa, Mario. "Alternative synthetic routes to hydrofluoroolefins". . p. 134 - 141. Retrieved 2015/11/10.
• 2、 Shilin, S. V.,Florensova, O. N.,Chernov, N. F.,Voronkov, M. G.. "α,α,ω-TRIHYDRO-α-HALOPERFLUOROALKANES". . p. 1697 - 1699. Retrieved 2007/10/02.