2,5-Diamino-2-methylpentanoic acid

Base Information

• Chemical Name: 2,5-Diamino-2-methylpentanoic acid
• CAS No.: 48047-94-5
• Molecular Formula: C6H14N2O2
• Molecular Weight: 146.19
• Hs Code.: 2922499990
• DSSTox Substance ID: DTXSID10963990
• Nikkaji Number: J347.979J
• ChEMBL ID: CHEMBL36743
• Mol file: 48047-94-5.mol

Synonyms:alpha-methyl ornithine;alpha-methylornithine;alpha-methylornithine carbonate, (L)-isomer;alpha-methylornithine dihydrochloride, (DL)-isomer;alpha-methylornithine monocarbonate, (DL)-isomer;alpha-methylornithine monohydrochloride;alpha-methylornithine monohydrochloride, (D)-isomer;alpha-methylornithine monohydrochloride, (DL)-isomer;alpha-methylornithine monohydrochloride, (DL)-isomer, (14)C-labeled;alpha-methylornithine monohydrochloride, (L)-isomer;alpha-methylornithine monosulfate;alpha-methylornithine, (DL)-isomer;alpha-methylornithine, (L)-isomer;DL-alpha-methylornithine

Chemical Property of 2,5-Diamino-2-methylpentanoic acid

Chemical Property:

• Vapor Pressure: 0.000211mmHg at 25°C
• Refractive Index: 1.505
• Boiling Point: 303.7 °C at 760 mmHg
• Flash Point: 137.5 °C
• PSA: 89.34000
• Density: 1.127 g/cm³
• LogP: 0.92790
• XLogP3: -3.4
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 146.105527694
• Heavy Atom Count: 10
• Complexity: 127

Purity/Quality:

99% ^*data from raw suppliers

ALPHA-METHYLORNITHINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CCCN)(C(=O)O)N

Technology Process of 2,5-Diamino-2-methylpentanoic acid

There total 2 articles about 2,5-Diamino-2-methylpentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(3-iodopropyl)phthalimide (5457-29-4) + methyl 2-(benzylideneamino)propanoate (40216-71-5) → α-Methylornithin (48047-94-5,48047-95-6)

Guidance literature:

Multistep reaction; (i) LDA, THF, (ii) /BRN= 157555/, (iii) aq. HCl;

DOI:10.1021/jm00199a009

Reference yield:

→ α-Methylornithin (48047-94-5,48047-95-6)

Guidance literature:

1a, 1. asymmetrische Synthese, (-> (+)-Menthyl-2,4-di-N-acetylamino-2-methylpentanoat (6a), 2. HCl, Hydrolyse;

DOI:10.1080/00021369.1978.10862948

upstream raw materials:

N-(3-iodopropyl)phthalimide

methyl 2-(benzylideneamino)propanoate

Refernces