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6a,7,8,9-Tetrahydro-2H-[1,4]dioxino[2',3':4,5]benzo[1,2-e]pyrrolo[2,1-b][1,3]oxazin-11(3H)-one

Base Information Edit
  • Chemical Name:6a,7,8,9-Tetrahydro-2H-[1,4]dioxino[2',3':4,5]benzo[1,2-e]pyrrolo[2,1-b][1,3]oxazin-11(3H)-one
  • CAS No.:191744-13-5
  • Molecular Formula:C13H13NO4
  • Molecular Weight:247.25
  • Hs Code.:2934999090
  • UNII:87V631480W
  • DSSTox Substance ID:DTXSID30912324
  • Nikkaji Number:J1.447.874D
  • Wikipedia:CX614
  • Wikidata:Q5014876
  • ChEMBL ID:CHEMBL599662
  • Mol file:191744-13-5.mol
6a,7,8,9-Tetrahydro-2H-[1,4]dioxino[2',3':4,5]benzo[1,2-e]pyrrolo[2,1-b][1,3]oxazin-11(3H)-one

Synonyms:2,3,6a,7,8,9-hexahydro-11H-(1,4)dioxino(2,3-g)pyrrolo(2,1-b)(1,3)benzoxazin-11-one;2H,3H,6aH-pyrrolidino(2'',1''-3',2')1,3-oxazino(6',5'-5,4)benzo(e)1, 4-dioxan-10-one;BDP 37;BDP-37;CX 614;CX-614;CX614

Suppliers and Price of 6a,7,8,9-Tetrahydro-2H-[1,4]dioxino[2',3':4,5]benzo[1,2-e]pyrrolo[2,1-b][1,3]oxazin-11(3H)-one
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Usbiological
  • CX 614
  • 10mg
  • $ 448.00
  • TRC
  • BDP37
  • 2mg
  • $ 90.00
  • Tocris
  • CX614 ≥99%(HPLC)
  • 10
  • $ 171.00
  • Tocris
  • CX614 ≥99%(HPLC)
  • 50
  • $ 717.00
  • Crysdot
  • 6a,7,8,9-Tetrahydro-2H-[1,4]dioxino[2',3':4,5]benzo[1,2-e]pyrrolo[2,1-b][1,3]oxazin-11(3H)-one 95+%
  • 250mg
  • $ 860.00
  • Crysdot
  • 6a,7,8,9-Tetrahydro-2H-[1,4]dioxino[2',3':4,5]benzo[1,2-e]pyrrolo[2,1-b][1,3]oxazin-11(3H)-one 95+%
  • 1g
  • $ 2150.00
  • Biosynth Carbosynth
  • BDP 37
  • 5 mg
  • $ 60.00
  • Biosynth Carbosynth
  • BDP 37
  • 10 mg
  • $ 100.00
  • Biosynth Carbosynth
  • BDP 37
  • 50 mg
  • $ 300.00
  • Biosynth Carbosynth
  • BDP 37
  • 25 mg
  • $ 175.00
Total 60 raw suppliers
Chemical Property of 6a,7,8,9-Tetrahydro-2H-[1,4]dioxino[2',3':4,5]benzo[1,2-e]pyrrolo[2,1-b][1,3]oxazin-11(3H)-one Edit
Chemical Property:
  • Vapor Pressure:3.82E-09mmHg at 25°C 
  • Melting Point:149-151°C 
  • Refractive Index:1.651 
  • Boiling Point:473.8 °C at 760 mmHg 
  • PKA:-1.49±0.20(Predicted) 
  • Flash Point:240.3 °C 
  • PSA:48.00000 
  • Density:1.45 g/cm3 
  • LogP:1.35020 
  • Storage Temp.:Refrigerator 
  • Solubility.:Chloroform, DMSO, Methanol 
  • XLogP3:1.5
  • Hydrogen Bond Donor Count:0
  • Hydrogen Bond Acceptor Count:4
  • Rotatable Bond Count:0
  • Exact Mass:247.08445790
  • Heavy Atom Count:18
  • Complexity:361
Purity/Quality:

99% *data from raw suppliers

CX 614 *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:C1CC2N(C1)C(=O)C3=CC4=C(C=C3O2)OCCO4
  • Uses It is one of a series of AMPA modulators matergic AMPA receptors.
Technology Process of 6a,7,8,9-Tetrahydro-2H-[1,4]dioxino[2',3':4,5]benzo[1,2-e]pyrrolo[2,1-b][1,3]oxazin-11(3H)-one

There total 8 articles about 6a,7,8,9-Tetrahydro-2H-[1,4]dioxino[2',3':4,5]benzo[1,2-e]pyrrolo[2,1-b][1,3]oxazin-11(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
With pyridine; copper(II) chloride monohydrate; oxygen; In m-xylene; at 130 ℃; for 24h;
DOI:10.1021/ol500670h
Guidance literature:
Multi-step reaction with 2 steps
1: zinc(II) chloride / chlorobenzene / Inert atmosphere; Reflux
2: dicobalt octacarbonyl; hydrogen / toluene / 20 h / 80 °C / 51716.2 Torr / Autoclave
With dicobalt octacarbonyl; hydrogen; zinc(II) chloride; In chlorobenzene; toluene;
DOI:10.1021/ol200111a
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