L-Ascorbic acid 6-stearate

Base Information

• Chemical Name: L-Ascorbic acid 6-stearate
• CAS No.: 10605-09-1
• Molecular Formula: C24H42O7
• Molecular Weight: 442.593
• Hs Code.: 2936270000
• Mol file: 10605-09-1.mol

Synonyms:L-Ascorbicacid, 6-stearate (8CI);Stearic acid, 6-ester with L-ascorbic acid (8CI);6-O-Stearylascorbic acid;Ascorbic acid 6-stearate;Ascorbyl 6-stearate;E 305;L-Ascorbic acid monostearate;L-Ascorbyl6-octadecanoate;

Chemical Property of L-Ascorbic acid 6-stearate

Chemical Property:

• Vapor Pressure: 1.01E-13mmHg at 25°C
• Melting Point: 117 °C
• Refractive Index: 1.516
• Boiling Point: 536 °C at 760 mmHg
• PKA: 3.96±0.10(Predicted)
• Flash Point: 168.5 °C
• PSA: 113.29000
• Density: 1.125 g/cm³
• LogP: 5.40500
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly, Sonicated)

Purity/Quality:

98%,99%, ^*data from raw suppliers

L-AscorbicAcid6-Stearate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: L-Ascorbic Acid 6-Stearate is used to specifically target anti-tumoral dehydrocrotonin nanoparticles.

Technology Process of L-Ascorbic acid 6-stearate

There total 3 articles about L-Ascorbic acid 6-stearate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

Methyl stearate (112-61-8) + ascorbic acid (50-81-7,98966-42-8) → L-ascorbic acid-6-O-octadecanoate (10605-09-1)

Guidance literature:

With Bulkholderia multivorans lipase-loaded alumina; at 80 ℃; for 0.666667h; regioselective reaction; Microwave irradiation; Neat (no solvent);

DOI:10.1080/00397910802513045

Reference yield:

Octadecanoic acid (S)-2-((R)-3,4-bis-benzyloxy-5-oxo-2,5-dihydro-furan-2-yl)-2-hydroxy-ethyl ester → L-ascorbic acid-6-O-octadecanoate (10605-09-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; under 3000.24 Torr;

DOI:10.1016/j.bmcl.2006.07.087

Reference yield:

stearic acid (57-11-4) + ascorbic acid (50-81-7,98966-42-8) → L-ascorbic acid-6-O-octadecanoate (10605-09-1)

Guidance literature:

With sulfuric acid;

upstream raw materials:

stearic acid

ascorbic acid

Methyl stearate

Refernces

• 1、 Spickenreither, Martin,Braun, Stephan,Bernhardt, Guenther,Dove, Stefan,Buschauer, Armin. "Novel 6-O-acylated vitamin C derivatives as hyaluronidase inhibitors with selectivity for bacterial lyases". . p. 5313 - 5316. Retrieved 2007/10/03.