(E)-(2-(hexa-3’,5’-dienyloxy)-4-methoxyphenyl)(1,1,1,3,3,3-hexamethyl-2-(trimethylsilyl)trisilan-2-yl)methanone

Base Information

• Chemical Name: (E)-(2-(hexa-3’,5’-dienyloxy)-4-methoxyphenyl)(1,1,1,3,3,3-hexamethyl-2-(trimethylsilyl)trisilan-2-yl)methanone
• CAS No.: 1569695-64-2
• Molecular Formula: C₂₃H₄₂O₃Si₄
• Molecular Weight: 478.927
• Mol file: 1569695-64-2.mol

Synonyms:(E)-(2-(hexa-3’,5’-dienyloxy)-4-methoxyphenyl)(1,1,1,3,3,3-hexamethyl-2-(trimethylsilyl)trisilan-2-yl)methanone

Chemical Property of (E)-(2-(hexa-3’,5’-dienyloxy)-4-methoxyphenyl)(1,1,1,3,3,3-hexamethyl-2-(trimethylsilyl)trisilan-2-yl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-(2-(hexa-3’,5’-dienyloxy)-4-methoxyphenyl)(1,1,1,3,3,3-hexamethyl-2-(trimethylsilyl)trisilan-2-yl)methanone

There total 6 articles about (E)-(2-(hexa-3’,5’-dienyloxy)-4-methoxyphenyl)(1,1,1,3,3,3-hexamethyl-2-(trimethylsilyl)trisilan-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-hexa-3,5-dien-1-ol (73670-87-8) → (E)-(2-(hexa-3’,5’-dienyloxy)-4-methoxyphenyl)(1,1,1,3,3,3-hexamethyl-2-(trimethylsilyl)trisilan-2-yl)methanone (1569695-64-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 25 °C / Inert atmosphere; Sonication

2.1: lithium hydroxide / tetrahydrofuran; water / 30 h / 50 °C

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 0 °C

4.1: potassium tert-butylate / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

4.2: 3 h / -78 °C / Inert atmosphere

With oxalyl dichloride; di-isopropyl azodicarboxylate; potassium tert-butylate; N,N-dimethyl-formamide; triphenylphosphine; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; 1.1: |Mitsunobu Displacement;

DOI:10.1039/c3cc49526d

Reference yield:

tetrakis(trimethylsilyl)silane (4098-98-0) + C14H15ClO3 → (E)-(2-(hexa-3’,5’-dienyloxy)-4-methoxyphenyl)(1,1,1,3,3,3-hexamethyl-2-(trimethylsilyl)trisilan-2-yl)methanone (1569695-64-2)

Guidance literature:

tetrakis(trimethylsilyl)silane; With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 3h; Inert atmosphere;

C₁₄H₁₅ClO₃; In tetrahydrofuran; at -78 ℃; for 3h; Inert atmosphere;

DOI:10.1039/c3cc49526d

Reference yield:

ethyl (E)-3,5-hexadienoate (74054-58-3) → (E)-(2-(hexa-3’,5’-dienyloxy)-4-methoxyphenyl)(1,1,1,3,3,3-hexamethyl-2-(trimethylsilyl)trisilan-2-yl)methanone (1569695-64-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / diethyl ether / 12.25 h / 0 - 20 °C / Inert atmosphere

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 25 °C / Inert atmosphere; Sonication

3.1: lithium hydroxide / tetrahydrofuran; water / 30 h / 50 °C

4.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 0 °C

5.1: potassium tert-butylate / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

5.2: 3 h / -78 °C / Inert atmosphere

With lithium aluminium tetrahydride; oxalyl dichloride; di-isopropyl azodicarboxylate; potassium tert-butylate; N,N-dimethyl-formamide; triphenylphosphine; lithium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; water; 2.1: |Mitsunobu Displacement;

DOI:10.1039/c3cc49526d

upstream raw materials:

ethyl (E)-3,5-hexadienoate

(E)-hexa-3,5-dien-1-ol

(2E,4E)-ethyl hexa-2,4-dienoate

tetrakis(trimethylsilyl)silane

Refernces