O,O,S-Trimethyl phosphorothioate

Base Information

• Chemical Name: O,O,S-Trimethyl phosphorothioate
• CAS No.: 152-20-5
• Molecular Formula: C3H9 O3 P S
• Molecular Weight: 156.142
• Hs Code.: 2920190090
• UNII: J4HYB2U9FX
• DSSTox Substance ID: DTXSID90164928
• Nikkaji Number: J60.500J
• Wikidata: Q83034020
• Mol file: 152-20-5.mol

Synonyms:O,O,S-trimethyl phosphorothioate;OOS-TMP

Chemical Property of O,O,S-Trimethyl phosphorothioate

Chemical Property:

• Boiling Point: 169°Cat760mmHg
• Flash Point: 56°C
• PSA: 70.64000
• Density: 1.211g/cm³
• LogP: 1.75030
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 156.00100232
• Heavy Atom Count: 8
• Complexity: 96.7

Purity/Quality:

99%, ^*data from raw suppliers

O,O,S-TrimethylEsterPhosphorothioicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COP(=O)(OC)SC
• Uses: O,O,S-Trimethyl Ester Phosphorothioic Acid was investigated for its immune suppression activities and was found that the acute administration of O,O,S-Trimethyl Ester Phosphorothioic Acid was benefici al to protect against lung toxicity varied with the sensitivity of the immune parameters.

Technology Process of O,O,S-Trimethyl phosphorothioate

There total 34 articles about O,O,S-Trimethyl phosphorothioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

methanol (67-56-1) + Benzyl-thiophosphoramidic acid O,S-dimethyl ester (71216-76-7) → O,O,S-trimethyl phosphorothioate (152-20-5)

Guidance literature:

With boron trifluoride methanol complex; 1) 0 deg C, 1h, 2) RT, overnight;

DOI:10.1021/jo00016a042

Reference yield: 80.0%

methanol (67-56-1) + N,N-dimethyl O,S-dimethyl phosphoramidothioate (65960-94-3,87000-69-9,25218-42-2) → O,O,S-trimethyl phosphorothioate (152-20-5)

Guidance literature:

With boron trifluoride methanol complex; 1) 0 deg C, 1h, 2) RT, overnight;

DOI:10.1021/jo00016a042

Reference yield: 74.0%

methanol (67-56-1) + Mio (10265-92-6) → O,O,S-trimethyl phosphorothioate (152-20-5)

Guidance literature:

With boron trifluoride methanol complex; 1) 0 deg C, 1h, 2) RT, overnight;

DOI:10.1021/jo00016a042

upstream raw materials:

diazomethane

O,S-dimethyl phosphorothiolate

methanol

O,O,O-trimethylthiophosphate

Downstream raw materials:

O,S-dimethyl phosphorothiolate

trimethylsulphonium iodide

Dimethyl ether

sodium O,S-dimethyl phosphorothioate

Refernces

• 1、 Mahajna, Mahmoud,Quistad, Gary B.,Casida, John E.. "S-methylation of O,O-dialkyl phosphorodithioic acids: O,O,S-trimethyl phosphorodithioate and phosphorothiolate as metabolites of dimethoate in mice". . p. 1202 - 1206. Retrieved 1996.
• 2、 Ramacharyulu,Praveen Kumar,Prasad,Srivastava. "Synthesis, characterization and photocatalytic activity of Ag-TiO2 nanoparticulate film". . p. 1309 - 1314. Retrieved 2015/02/02.
• 3、 Segal-Rosenheimer, Michal,Dubowski, Yael. "Photolysis of methyl-parathion thin films: Products, kinetics and quantum yields under different atmospheric conditions". scheme or table. p. 193 - 202. Retrieved 2010/10/01.