Minovlar

Base Information

• Chemical Name: Minovlar
• CAS No.: 68-22-4
• Molecular Formula: C20H26O2
• Molecular Weight: 298.425
• Hs Code.: 29144000
• Mol file: 68-22-4.mol

Synonyms:Minovlar;Ovcon (Salt/Mix);Neocon (Salt/Mix);Binovum (Salt/Mix);Modicon (Salt/Mix);Noriday (Salt/Mix);Brevicon (Salt/Mix);Brevinor (Salt/Mix);Synphase (Salt/Mix);Nora-BE (Salt/Mix);Nor-Q.D.;Tri-Norinyl (Salt/Mix);component of Norimin (Salt/Mix);component of Ovysmen (Salt/Mix);Norethin 1/35 E (Salt/Mix);Ortho-novum 1/35 (Salt/Mix);Ortho-novum 1/50 (Salt/Mix);component of Trinovum (Salt/Mix);Ortho-novum 7/7/7 (Salt/Mix);19-Norpregn-4-en-20-yn-3-one, 17-hydroxy-, (17.alpha.)-;component of Norinyl-1 (Salt/Mix);component of Norquentiel (Salt/Mix);component of Neocon 1/35 (Salt/Mix);component of Norinyl 1-35 (Salt/Mix);17-Ethynyl-17-hydroxyestr-4-en-3-one #;17.alpha.-Ethynyl-17-hydroxyest-4-en-3-one;17.alpha.-Ethynyl-3-oxo-4-estren-17.beta.-ol;4-Estren-17.alpha.-ethynyl-17.beta.-ol-3-one;17.beta.-Hydroxy-17.alpha.-ethynylestr-4-en-3-one;17-.alpha.-Ethynyl-17-.beta.-hydroxy-4-estren-3-one;17-Hydroxy-17-.alpha.-19-norpregn-4-en-20-yn-3-one;(17-.alpha.)-17-Hydroxy-19-norpregn-4-en-20-yn-3-one;17-.alpha.-19-Norpregn-4-en-20-yn-3-one, 17-hydroxy-;19-Norandrost-4-en-3-one, 17.alpha.-ethynyl-17.beta.-hydroxy-;VIKNJXKGJWUCNN-NSDIEPNESA-N;ENT;NET

Chemical Property of Minovlar

Chemical Property:

• Appearance/Colour: Off-white to pale yellow solid
• Vapor Pressure: 7.22E-10mmHg at 25°C
• Melting Point: 205-206 °C(lit.)
• Refractive Index: 1.577
• Boiling Point: 447 °C at 760 mmHg
• PKA: 13.09±0.40(Predicted)
• Flash Point: 190.5 °C
• PSA: 37.30000
• Density: 1.15 g/cm³
• LogP: 3.49250
• Storage Temp.: -20°C Freezer
• Solubility.: chloroform: ≥50 mg/mL, clear, colorless
• Water Solubility.: 7.043mg/L(25 oC)
• XLogP3: 3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 298.193280068
• Heavy Atom Count: 22
• Complexity: 594

Purity/Quality:

99% ^*data from raw suppliers

Norethindrone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 40-36/37/38-20/21/22
• Safety Statements: 22-36/37/39-45-37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC12CCC3C(C1CCC2(C#C)O)CCC4=CC(=O)CCC34
• Isomeric SMILES: CC12CCC3C(C1CC[C@@]2(C#C)O)CCC4=CC(=O)CCC34
• Description: Norethindrone is a progestin (a synthetic substance with properties similar to progesterone) that is best known as the first female oral contraceptive, or the “pill.”Norethindrone’s global impact on society and culture has made it one of the most important inventions in history.
• Uses: Progestin contraceptives work by producing pregnant-like conditions in a female to preventovulation.During pregnancy, progesterone is released by the placenta during development ofthe fetus.This in turn suppresses development of egg follicles and ovulation. Progestins mimicthis condition and thus prevent or delay ovulation.Oral contraceptives currently use progestinand estrogen in combination to prevent ovulation and thicken cervical mucus.The latter makeit harder for sperm to enter the uterus and for an egg to implant on the uterine wall. A synthetic progestin Progesteron. Norethindrone and acetate in combination with estrogen as contraceptive (oral). It is reasonably anticipated to be a human carcinogen
• Therapeutic Function: Progestin
• Clinical Use: Progestogen: Breast cancer, contraception, dysfunctional uterine bleeding, menorrhagia, dysmenorrhoea, endometriosis, premenstrual syndrome, postponement of menstruation
• Drug interactions: Potentially hazardous interactions with other drugs Antibacterials: metabolism of progestogens accelerated by rifamycins (reduced contraceptive effect). Anticoagulants: progestogens antagonise anticoagulant effect of phenindione; may enhance or reduce anticoagulant effect of coumarins. Antidepressants: contraceptive effect reduced by St John’s Wort - avoid. Antiepileptics: metabolism accelerated by carbamazepine, eslicarbazepine, fosphenytoin, lamotrigine, oxcarbazepine, phenobarbital, phenytoin, rufinamide and topiramate (reduced contraceptive effect); concentration of lamotrigine reduced; concentration reduced by high dose perampanel. Antifungals: reduced contraceptive effect with griseofulvin. Antivirals: contraceptive effect reduced by efavirenz; metabolism accelerated by nevirapine (reduced contraceptive effect); atazanavir increases norethisterone concentration. Aprepitant: possible contraceptive failure. Bosentan: possible contraceptive failure. Ciclosporin: progestogens inhibit metabolism of ciclosporin (increased plasma concentration). Cytotoxics: possibly reduced contraceptive effect with crizotinib, dabrafenib, olaparib and vemurafenib. Dopaminergics: concentration of selegiline increased - avoid. Fosaprepitant: possible contraceptive failure. Lumacaftor: possible contraceptive failure. Tacrolimus: tacrolimus levels are greatly increased - avoid (anecdotal evidence). Ulipristal: contraceptive effect of progestogens possibly reduced.

Technology Process of Minovlar

There total 37 articles about Minovlar which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

estra-4-ene-3,17-dione (734-32-7) + acetylene (74-86-2,25067-58-7) → norethisterone (68-22-4)

Guidance literature:

estra-4-ene-3,17-dione; With potassium hydroxide; In toluene; tert-butyl alcohol; for 0.166667h; under 760.051 Torr; Reflux; Industrial scale;

acetylene; In tert-butyl methyl ether; toluene; for 6h; Industrial scale;

Reference yield: 88.0%

3-ethoxy-19-nor-3,5-androstadiene-17-one (2863-88-9) + acetylene (74-86-2,25067-58-7) → norethisterone (68-22-4)

Guidance literature:

With potassium; In tert-Amyl alcohol; toluene; at 20 ℃; Inert atmosphere;

Reference yield: 86.0%

Noretynodrel (5541-86-6,6073-48-9,13577-86-1,25918-97-2,57287-11-3,68-23-5) → norethisterone (68-22-4)

Guidance literature:

With potassium hydroxide; In methanol; water; Ambient temperature;

DOI:10.1021/jo01302a013

upstream raw materials:

estrone 3-methyl ether

3-methoxy-19-nor-17βH-pregna-2,5(10)-dien-20-yn-17-ol

estra-4-ene-3,17-dione

acetylene

Downstream raw materials:

3,17-diacetoxy-19-nor-17βH-pregna-3,5-dien-20-yne

estra-4-ene-3,17-dione

norethisterone 3-(5'-methyl-2'-furyl)propanoate

norethisterone 5-phenylpentanoate

Refernces

• 1、 -. "Synthetic method of tibolone". Paragraph 0028-0031. . Retrieved 2020/05/01.
• 2、 -. "A 19-nor-4-androstene -3,17-dione method for the preparation of". Paragraph 0040-0043. . Retrieved 2017/04/03.