Methyl Bromopyruvate

Base Information

• Chemical Name: Methyl Bromopyruvate
• CAS No.: 7425-63-0
• Molecular Formula: C4H5 Br O3
• Molecular Weight: 180.986
• Hs Code.: 2918300090
• Mol file: 7425-63-0.mol

Synonyms:Pyruvicacid, bromo-, methyl ester (6CI,7CI,8CI); Methyl 3-bromo-2-oxopropanoate;Methyl bromopyruvate; NSC 526776

Chemical Property of Methyl Bromopyruvate

Chemical Property:

• Vapor Pressure: 0.65mmHg at 25°C
• Melting Point: 5°C(lit.)
• Refractive Index: n20/D 1.480
• Boiling Point: 186.8oC at 760 mmHg
• Flash Point: 125oC
• PSA: 43.37000
• Density: 1.70
• LogP: 0.12340
• Storage Temp.: 2-8°C

Purity/Quality:

99.9% ^*data from raw suppliers

Methyl bromopyruvate ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl bromopyruvate was used in the synthesis of 2-(4-amino-4-carboxybutyl)thiazole-4-carboxylic acid and methyl-1-(bromomethyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate.

Technology Process of Methyl Bromopyruvate

There total 4 articles about Methyl Bromopyruvate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

(S)-Methyl lactate (27871-49-4,2155-30-8) → methyl 3-bromo-2-oxopropanoate (7425-63-0)

Guidance literature:

With N-Bromosuccinimide; In tetrachloromethane; for 6h; Reflux;

DOI:10.1055/s-0032-1317810

Reference yield:

pyruvic acid methyl ester (600-22-6) → methyl 3-bromo-2-oxopropanoate (7425-63-0)

Guidance literature:

With tetrachloromethane; bromine; am Licht;

Reference yield:

methanol (67-56-1) + bromopyruvic acid (1113-59-3) → methyl 3-bromo-2-oxopropanoate (7425-63-0)

Guidance literature:

With hydrogenchloride; at 20 ℃; for 15h;

upstream raw materials:

pyruvic acid methyl ester

methanol

bromopyruvic acid

(S)-Methyl lactate

Downstream raw materials:

dimethyl 2,2′-(1,4-phenylene)dithiazole-4-carboxylate

C₂₂H₂₄N₂O₂

C₁₉H₂₄N₂O₄

dimethyl 2-methylfuran-3,4-dicarboxylate

Refernces

• 1、 Lu, Jin-Yong,Riedrich, Matthias,Wojtas, K.Philip,Arndt, Hans-Dieter. "Assembly of the nosiheptide A-ring: A fruitful lesson". supporting information. p. 1300 - 1311. Retrieved 2013/07/04.
• 2、 Noguchi, Hirohide,Aoyama, Toyohiko,Shioiri, Takayuki. "Total synthesis and absolute configuration of radiosumin, a strong trypsin inhibitor from the blue-green alga Plectonema radiosum". . p. 471 - 504. Retrieved 2007/10/03.