Ethyl 2-(isopropylideneaminooxy)propionate

Base Information

• Chemical Name: Ethyl 2-(isopropylideneaminooxy)propionate
• CAS No.: 54716-29-9
• Molecular Formula: C₈H₁₅NO₃
• Molecular Weight: 173.212
• Hs Code.: 2925290090
• Mol file: 54716-29-9.mol

Synonyms:Propionicacid, 2-[(isopropylideneamino)oxy]-, ethyl ester (7CI); NSC 519146

Chemical Property of Ethyl 2-(isopropylideneaminooxy)propionate

Chemical Property:

• Vapor Pressure: 0.168mmHg at 25°C
• Boiling Point: 213°C at 760 mmHg
• Flash Point: 74.1°C
• PSA: 47.89000
• Density: 1g/cm³
• LogP: 1.35040

Purity/Quality:

98%min ^*data from raw suppliers

2-(ISOPROPYLIDENEAMINO)OXY-PROPIONIC ACID ETHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 2-(isopropylideneaminooxy)propionate

There total 1 articles about Ethyl 2-(isopropylideneaminooxy)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

Ethyl 2-bromopropionate (535-11-5,41978-69-2) + acetone oxime (127-06-0) → 2-{[(1-methylethylidene)amino]oxy}-propanoic acid, ethyl ester (54716-29-9)

Guidance literature:

With sodium ethanolate; at 0 - 20 ℃; for 18h;

Reference yield: 37.0%

2-{[(1-methylethylidene)amino]oxy}-propanoic acid, ethyl ester (54716-29-9) → α-(isopropylidenaminooxy)-propionic acid (2009-88-3,2009-89-4,2009-90-7,5001-36-5)

Guidance literature:

2-{[(1-methylethylidene)amino]oxy}-propanoic acid, ethyl ester; With sodium hydroxide; water; at 70 ℃; for 0.333333h;

With hydrogenchloride; In water; at 20 ℃; pH=2;

Reference yield:

2-{[(1-methylethylidene)amino]oxy}-propanoic acid, ethyl ester (54716-29-9) → (+)-α-(Isopropylidenamino-oxy)-propionsaeure (2009-88-3,2009-89-4,2009-90-7,5001-36-5)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH

With sodium hydroxide;

DOI:10.1021/jo01015a545

upstream raw materials:

Ethyl 2-bromopropionate

acetone oxime

Downstream raw materials:

α-(isopropylidenaminooxy)-propionic acid

(+)-α-(Isopropylidenamino-oxy)-propionsaeure

(-)-α-(Isopropylidenamino-oxy)-propionsaeure

Refernces

• 1、 -. "Camptothecin derivatives as chemoradiosensitizing agents". Page/Page column 34. . Retrieved 2008/06/13.