Hydrocortisone sodium succinate

Base Information

• Chemical Name: Hydrocortisone sodium succinate
• CAS No.: 125-04-2
• Molecular Formula: C25H33NaO8
• Molecular Weight: 502.59
• Mol file: 125-04-2.mol

Synonyms:U 4905;Cortisol,21-(hydrogen succinate), monosodium salt (8CI);Cortisol, succinate, sodium salt (6CI);A-HydroCort;Buccalsone;Corlan;Cortisol hemisuccinate sodium salt;Cortisol sodium hemisuccinate;Cortisolsodium succinate;EF-Cortelan Soluble;Emi-Corlin;Flebocortid;Hydrocortisone21-hemisuccinate sodium salt;Hydrocortisone 21-succinate sodium salt;Hydrocortisone hemisuccinate sodium salt;Hydrocortisone sodiumsuccinate;Intracort;Nordicort;Oralsone;Sodium 17-hydroxycorticosterone 21-succinate;Sodium hydrocortisone 21-hemisuccinate;Solu-Cortef;Solu-Glyc;Hydrocortisone sodium succinate;

Chemical Property of Hydrocortisone sodium succinate

Chemical Property:

• Vapor Pressure: 9.36E-22mmHg at 25°C
• Melting Point: 169.0-171.2°
• Boiling Point: 685.5 °C at 760 mmHg
• Flash Point: 231.1 °C
• PSA: 141.03000
• LogP: 0.86260
• Storage Temp.: −20°C
• Solubility.: H2O: 50 mg/mL

Purity/Quality:

83.1%,83.3%, ^*data from raw suppliers

HydrocortisoneHemisuccinateSodiumSalt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Hydrocortisone Hemisuccinate Sodium is a derivative of the glucocorticoid Hydrocortisone (H714615). Hydrocortisone Hemisuccinate Sodium is used as an anti-inflammatory agent. Hydrocortisone Hemisuccinate Sodium is widely used in the treatment of asthma, endocrine disorders, dermatological disorders, allergic states, etc. Hydrocortisone sodium succinate is a derivative of the glucocorticoid Hydrocortisone (H714615). Hydrocortisone Hemisuccinate Sodium is used as an anti-inflammatory agent. Hydrocortisone sodium succinate is widely used in the treatment of asthma, endocrine disorders, dermatological disorders, allergic states, etc. Hydrocortisone 21-hemisuccinate is a water-soluble form of the endogenous hormone cortisol. It can bind to glucocorticoid receptors, initiating the transcription of anti-inflammatory and immunosuppressive mediators and inhibiting proinflammatory cytokine activity (IC50 = 6.7 μM for IL-6). It is commonly used to supplement media for long-term epithelial or endothelial cell cultures and to differentiate pluripotent stem cells.
• Clinical Use: #N/A
• Drug interactions: Potentially hazardous interactions with other drugs Aldesleukin: avoid concomitant use. Antibacterials: metabolism accelerated by rifampicin; metabolism possibly inhibited by erythromycin; concentration of isoniazid possibly reduced. Anticoagulants: efficacy of coumarins and phenindione may be altered. Antiepileptics: metabolism accelerated by carbamazepine, fosphenytoin, phenobarbital, phenytoin and primidone. Antifungals: increased risk of hypokalaemia with amphotericin - avoid; metabolism possibly inhibited by itraconazole and ketoconazole. Antivirals: concentration possibly increased by ritonavir. Ciclosporin: rare reports of convulsions in patients on ciclosporin and high-dose corticosteroids. Cobicistat: concentration of hydrocortisone possibly increased - increased risk of adrenal suppression. Diuretics: enhanced hypokalaemic effects of acetazolamide, loop diuretics and thiazide diuretics. Vaccines: high dose corticosteroids can impair immune response to vaccines - avoid concomitant use with live vaccines.