2-(2,6-dichlorophenyl)pyrimidine

Base Information

• Chemical Name: 2-(2,6-dichlorophenyl)pyrimidine
• CAS No.: 1182190-65-3
• Molecular Formula: C₁₀H₆Cl₂N₂
• Molecular Weight: 225.077
• Mol file: 1182190-65-3.mol

Synonyms:2-(2,6-dichlorophenyl)pyrimidine

Chemical Property of 2-(2,6-dichlorophenyl)pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2,6-dichlorophenyl)pyrimidine

There total 3 articles about 2-(2,6-dichlorophenyl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-phenylpyrimidine (7431-45-0) → 2-(2,6-dichlorophenyl)pyrimidine (1182190-65-3)

Guidance literature:

With palladium diacetate; copper(II) trifluoroacetate; calcium chloride; In acetic acid; at 110 ℃; for 7h;

DOI:10.1002/adsc.200900778

Reference yield: 92.0%

2-phenylpyrimidine (7431-45-0) → 2-(2,6-dichlorophenyl)pyrimidine (1182190-65-3) + 2-(2-chlorophenyl)pyrimidine

Guidance literature:

With palladium diacetate; copper(II) trifluoroacetate; calcium chloride; In acetic anhydride; acetic acid; at 110 ℃; for 4.5h;

DOI:10.1002/adsc.200900778

Reference yield:

phenylboronic acid (98-80-6) → 2-(2,6-dichlorophenyl)pyrimidine (1182190-65-3) + 2-(2-chlorophenyl)pyrimidine

Guidance literature:

Multi-step reaction with 2 steps

1: palladium diacetate; oxygen; sodium carbonate / 1,4-dioxane / 90 °C

2: oxygen; copper(II) nitrate trihydrate; lithium chloride; acetic acid / 35 h / 150 °C / 760.05 Torr / Sealed tube

With copper(II) nitrate trihydrate; oxygen; palladium diacetate; sodium carbonate; acetic acid; lithium chloride; In 1,4-dioxane; 1: |Suzuki Coupling;

DOI:10.1039/c3ob40185e

upstream raw materials:

2-phenylpyrimidine

phenylboronic acid

Refernces

• 1、 Mo, Song,Zhu, Yamin,Shen, Zengming. "Copper-catalyzed aromatic C-H bond halogenation with lithium halides under aerobic conditions". supporting information. p. 2756 - 2760. Retrieved 2013/05/08.
• 2、 Zheng, Xiaojian,Song, Bingrui,Li, Guifei,Liu, Bingxin,Deng, Hongmei,Xu, Bin. "Direct synthesis of ortho-dihalogenated arylpyrimidines using calcium halides as halogen sources". supporting information; experimental part. p. 6641 - 6645. Retrieved 2011/02/21.