2-(3-methoxyphenyl)quinazoline

Base Information

• Chemical Name: 2-(3-methoxyphenyl)quinazoline
• CAS No.: 1208259-21-5
• Molecular Formula: C₁₅H₁₂N₂O
• Molecular Weight: 236.273
• Mol file: 1208259-21-5.mol

Synonyms:2-(3-methoxyphenyl)quinazoline

Chemical Property of 2-(3-methoxyphenyl)quinazoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 2-(3-methoxyphenyl)quinazoline

There total 23 articles about 2-(3-methoxyphenyl)quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-(3-methoxyphenyl)-1,2,3,4-tetrahydroquinazoline (1514933-78-8) → 2-(3-methoxyphenyl)quinazoline (1208259-21-5)

Guidance literature:

With 3,5-Di-tert-butylcatechol; laccase from Trametes versicolor; oxygen; In aq. phosphate buffer; acetonitrile; at 45 ℃; for 20h; pH=4.5; Reagent/catalyst; Enzymatic reaction;

DOI:10.1002/ejoc.201800466

Reference yield: 91.0%

3-METHOXYBENZYLAMINE (5071-96-5) + 2-amino-1-benzylamine (4403-69-4) → 2-(3-methoxyphenyl)quinazoline (1208259-21-5)

Guidance literature:

With iodine; oxygen; at 130 ℃; for 2h; Green chemistry;

DOI:10.1039/c6ob02163h

Reference yield: 88.0%

3-methoxybenzyl alcohol (6971-51-3) + 2-amino-1-benzylamine (4403-69-4) → 2-(3-methoxyphenyl)quinazoline (1208259-21-5)

Guidance literature:

With C₁₈H₂₆IrN₃O₂⁽²⁺⁾*2CF₃O₃S^(1-); In water; for 24h; Schlenk technique; Inert atmosphere; Reflux; Green chemistry;

DOI:10.1039/c8gc03744b

upstream raw materials:

2-iodobenzaldehyde

3-methoxybenzene-1-carboximidamide hydrogenchloride

3-methoxy-benzaldehyde

2-amino-1-benzylamine

Refernces

• 1、 Luo, Lan,Liu, Hongqiang,Zeng, Wei,Hu, Wenkang,Wang, Dawei. "BTP-Rh@g-C3N4 as an efficient recyclable catalyst for dehydrogenation and borrowing hydrogen reactions". . . Retrieved 2021/11/16.
• 2、 -. "A cobalt-catalyzed method for synthesizing quinoline and quinazoline compounds". Paragraph 0021; 0065. . Retrieved 2022/01/10.