N-(2-Acetylphenyl)acetamide

Base Information

• Chemical Name: N-(2-Acetylphenyl)acetamide
• CAS No.: 5234-26-4
• Molecular Formula: C10H11NO2
• Molecular Weight: 177.203
• Hs Code.: 2924299090
• NSC Number: 12469
• UNII: F1K8P8A71N
• DSSTox Substance ID: DTXSID80200369
• Nikkaji Number: J79.112A
• Wikidata: Q72435639
• Mol file: 5234-26-4.mol

Synonyms:N-(2-Acetylphenyl)acetamide;5234-26-4;N-(2-acetyl-phenyl)-acetamide;2'-Acetamidoacetophenone;o-Acetamidoacetophenone;2'-Acetylacetanilide;Acetamide, N-(2-acetylphenyl)-;ACETANILIDE, 2'-ACETYL-;2'-(Acetylamino)acetophenone;2-ACETAMIDOACETOPHENONE;Acetamido-2 acetophenone [French];Acetamido-2 acetophenone;NSC 12469;BRN 0908950;N-(2-acetyl-phenyl)acetamide;F1K8P8A71N;NSC-12469;4-14-00-00092 (Beilstein Handbook Reference);NSC12469;UNII-F1K8P8A71N;SCHEMBL505353;N-(2-Acetylphenyl)-acetamide;N-(2-ethanoylphenyl)ethanamide;DTXSID80200369;1-[2-(acetylamino)phenyl]ethanone;N-(O-ACETYLPHENYL)ACETAMIDE;MFCD00032277;AKOS000190275;2'-(N-ACETYLAMINO)ACETOPHENONE;AB19004;BS-28554;N-[2-(1-oxo-1-ethanyl)phenyl]acetamide;N-[2-(1-oxo-1-ethanyl)-phenyl]acetamide;CS-0453237;FT-0693007;A829039;Z27879706

Chemical Property of N-(2-Acetylphenyl)acetamide

Chemical Property:

• Vapor Pressure: 1.37E-05mmHg at 25°C
• Melting Point: 77 °C(Solv: ethyl ether (60-29-7))
• Refractive Index: 1.57
• Boiling Point: 367.4 °C at 760 mmHg
• PKA: 14.56±0.70(Predicted)
• Flash Point: 165.1 °C
• PSA: 46.17000
• Density: 1.15 g/cm³
• LogP: 1.92060
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 177.078978594
• Heavy Atom Count: 13
• Complexity: 213

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-(2-Acetylphenyl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C1=CC=CC=C1NC(=O)C

Technology Process of N-(2-Acetylphenyl)acetamide

There total 30 articles about N-(2-Acetylphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-aminoacetophenone (551-93-9) + acetyl chloride (75-36-5) → N-(2-acetylphenyl)acetamide (5234-26-4)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1016/j.bmc.2006.06.047

Reference yield: 95.0%

2,3-dimethylindole (91-55-4) → N-(2-acetylphenyl)acetamide (5234-26-4)

Guidance literature:

With suspension-cultured cells from Catharanthus roseus; dihydrogen peroxide; In various solvent(s); at 25 ℃; for 0.5h;

DOI:10.1016/j.tetlet.2004.08.175

Reference yield: 94.0%

acetic anhydride (108-24-7) + 2-aminoacetophenone (551-93-9) → N-(2-acetylphenyl)acetamide (5234-26-4)

Guidance literature:

for 3h; Ambient temperature;

upstream raw materials:

2,3-dimethylindole

2,3-dimethyl-3-(hydroperoxy)indolenine

acetic anhydride

2-aminoacetophenone

Downstream raw materials:

[E]-3-phenyl-1-(2-acetamidophenyl)prop-2-en-1-one

4-methylquinolin-2-ol

N-(2-acetyl-4-nitro-phenyl)-acetamide

acetic acid-(2-acetyl-6-nitro-anilide)

Refernces

• 1、 Llopis, Natalia,Gisbert, Patricia,Baeza, Alejandro. "Oxidative Cleavage of Indoles Mediated by Urea Hydrogen Peroxide or H2O2 in Polar Solvents". supporting information. p. 3245 - 3249. Retrieved 2021/06/08.
• 2、 Du, Yunfei,Ouyang, Yaxin,Wang, Xi,Wang, Xiaofan,Yu, Zhenyang,Zhao, Bingyue,Zhao, Kang. "PhIO-Mediated oxidative dethioacetalization/dethioketalization under water-free conditions". . p. 48 - 65. Retrieved 2021/06/16.