N'-[1-(2,4-Dihydroxyphenyl)ethylidene]-4-pyridinecarbohydrazide

Base Information

• Chemical Name: N'-[1-(2,4-Dihydroxyphenyl)ethylidene]-4-pyridinecarbohydrazide
• CAS No.: 792-38-1
• Molecular Formula: C14H13N3O3
• Molecular Weight: 271.276
• Mol file: 792-38-1.mol

Synonyms:resacetophenone isoniazid hydrazone;2,4-Dihydroxy-acetophenon-isonicotinoylhydrazon;2,4-dihydroxyacetophenone isonicotinoyl hydrazone;

Chemical Property of N'-[1-(2,4-Dihydroxyphenyl)ethylidene]-4-pyridinecarbohydrazide

Chemical Property:

• Boiling Point: 399.3oC at 760 mmHg
• Flash Point: 195.3oC
• PSA: 94.81000
• Density: 1.379g/cm3
• LogP: 2.03770

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N'-[1-(2,4-Dihydroxyphenyl)ethylidene]-4-pyridinecarbohydrazide

There total 6 articles about N'-[1-(2,4-Dihydroxyphenyl)ethylidene]-4-pyridinecarbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

isoniazid (54-85-3,7640-37-1) + 2',4'-dihydroxy-4-acetophenone (89-84-9) → N'-[1-(2,4-dihydroxyphenyl)ethylidene]isonicotinohydrazide (792-38-1)

Guidance literature:

In ethanol; for 4h; Reflux;

DOI:10.1021/je200370d

Reference yield: 35.0%

isoniazid (54-85-3,7640-37-1) + 2',4'-dihydroxy-4-acetophenone (89-84-9) → (E)-N'-[1-(2,4-dihydroxyphenyl)ethyliden]isonicotinoylhydrazide (792-38-1)

Guidance literature:

With acetic acid; In ethanol; for 9h; Reflux;

DOI:10.1021/tx100359t

Reference yield:

pyridine-4-carboxylic acid (55-22-1) → N'-[1-(2,4-dihydroxyphenyl)ethylidene]isonicotinohydrazide (792-38-1)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / Reflux

2: hydrazine hydrate / ethanol / Reflux

3: ethanol / Reflux

With sulfuric acid; hydrazine hydrate; In ethanol;

DOI:10.1007/s00044-011-9705-2

upstream raw materials:

isoniazid

2',4'-dihydroxy-4-acetophenone

pyridine-4-carboxylic acid

isonicotinic acid ethylester

Downstream raw materials:

2',4'-dihydroxy-4-acetophenone

Refernces

• 1、 Hall, Kacey C.,Franks, Andrew T.,McAtee, Rory C.,Wang, Michael S.,Lu, Vivian I.,Franz, Katherine J.. "Metal-binding hydrazone photoswitches for visible light reactivity and variable relaxation kinetics". . p. 1604 - 1612. Retrieved 2017/11/16.
• 2、 Hruskova, Katerina,Kovarikova, Petra,Bendova, Petra,Haskova, Pavlina,MacKova, Eliska,Stariat, Jan,Vavrova, Anna,Vavrova, Katerina,Simunek, Tomas. "Synthesis and initial in vitro evaluations of novel antioxidant aroylhydrazone iron chelators with increased stability against plasma hydrolysis". experimental part. p. 290 - 302. Retrieved 2012/04/11.