Hydron;1-methyl-4-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaenylidene)piperidine;chloride

Base Information

• Chemical Name: Hydron;1-methyl-4-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaenylidene)piperidine;chloride
• CAS No.: 969-33-5
• Molecular Formula: C21H21N^.HCl
• Molecular Weight: 323.865
• Hs Code.: 2933399090
• Mol file: 969-33-5.mol

Synonyms:

Chemical Property of Hydron;1-methyl-4-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaenylidene)piperidine;chloride

Chemical Property:

• Melting Point: 254-256.5 °C(Solv: ethanol (64-17-5); ethyl ether (60-29-7))
• Boiling Point: 440.1 °C at 760 mmHg
• Flash Point: 194.5 °C
• PSA: 3.24000
• LogP: 5.43780
• Storage Temp.: Store at RT
• Solubility.: ethanol: soluble
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 323.1440774
• Heavy Atom Count: 23
• Complexity: 423

Purity/Quality:

98.5%-100.5% ^*data from raw suppliers

CYPROHEPTADINEHCl ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: [H+].CN1CCC(=C2C3=CC=CC=C3C=CC4=CC=CC=C42)CC1.[Cl-]
• Uses: Antipruritic;5-HT antagonist Cyproheptadine hydrochloride is an antihistamine in which antiserotonin activity has been demonstrated both in vivo and in vitro. As yet, however, there is no evidence that this action contributes to clinical therapeutic effects. Anticholinergic and sedative effects are observed. Cyproheptadine may be more effective than other H1 blockers in the management of cold urticaria.
• Clinical Use: #N/A

Technology Process of Hydron;1-methyl-4-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaenylidene)piperidine;chloride

There total 2 articles about Hydron;1-methyl-4-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaenylidene)piperidine;chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(1-methyl-4-piperidyl)-5H-dibenzocyclohepten-5-ol (3967-32-6) → cyproheptadine hydrochloride (969-33-5)

Guidance literature:

With hydrogenchloride; In ethanol; water; at 90 ℃; for 1h; Large scale;

Reference yield:

→ cyproheptadine hydrochloride (969-33-5)

Guidance literature:

Reference yield:

cyproheptadine hydrochloride (969-33-5) → 4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)piperidine (14051-46-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydroxide / ethyl acetate; water

1.2: Reflux

2.1: potassium hydroxide; water; ethanol / 48 h / Reflux

With ethanol; water; potassium hydroxide; sodium hydroxide; In water; ethyl acetate;

upstream raw materials:

5-(1-methyl-4-piperidyl)-5H-dibenzocyclohepten-5-ol

Downstream raw materials:

Cyproheptadine 10,11-epoxide

4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)piperidine

Refernces

• 1、 -. "Water dispersion containing ultrafine particles of organic compounds". . . Retrieved 2008/06/13.