C₂₄H₂₅NO

Base Information

• Chemical Name: C₂₄H₂₅NO
• CAS No.: 1588488-70-3
• Molecular Formula: C₂₄H₂₅NO
• Molecular Weight: 343.469
• Mol file: 1588488-70-3.mol

Synonyms:C₂₄H₂₅NO

Chemical Property of C₂₄H₂₅NO

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of C₂₄H₂₅NO

There total 5 articles about C₂₄H₂₅NO which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

benzyl bromide (100-39-0) + 1-diphenylmethyl-2-hydroxymethylazetidine (72351-68-9) → C24H25NO (1588488-70-3)

Guidance literature:

1-diphenylmethyl-2-hydroxymethylazetidine; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.333333h; Inert atmosphere;

benzyl bromide; In N,N-dimethyl-formamide; mineral oil; at 20 - 60 ℃; for 12.5h; Inert atmosphere;

With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 60 ℃; for 5h; Inert atmosphere;

DOI:10.1002/ejoc.201301536

Reference yield:

C17H18N2O (1588488-75-8) → C24H25NO (1588488-70-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: thionyl chloride / dichloromethane / 2 h / 20 °C / Inert atmosphere

2.1: potassium tert-butylate / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

3.1: sulfuric acid / 144 h / 60 °C / Inert atmosphere

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 50 °C / Inert atmosphere

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C / Inert atmosphere

5.2: 12.5 h / 20 - 60 °C / Inert atmosphere

5.3: 5 h / 60 °C / Inert atmosphere

With lithium aluminium tetrahydride; thionyl chloride; sulfuric acid; potassium tert-butylate; sodium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;

DOI:10.1002/ejoc.201301536

Reference yield:

C17H17ClN2 (1588488-76-9) → C24H25NO (1588488-70-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium tert-butylate / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

2.1: sulfuric acid / 144 h / 60 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 50 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C / Inert atmosphere

4.2: 12.5 h / 20 - 60 °C / Inert atmosphere

4.3: 5 h / 60 °C / Inert atmosphere

With lithium aluminium tetrahydride; sulfuric acid; potassium tert-butylate; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;

DOI:10.1002/ejoc.201301536

upstream raw materials:

C₁₇H₁₈N₂O

C₁₇H₁₇ClN₂

1-benzhydryl-azetidine-2-carbonitrile

N-Benzhydryl-2-carbethoxyazetidine

Downstream raw materials:

C₂₅H₂₈NO⁽¹⁺⁾*CF₃O₃S^(1-)

C₂₅H₂₇NO

Refernces

• 1、 Drouillat, Bruno,D'Aboville, Edouard,Bourdreux, Flavien,Couty, Fran?ois. "Synthesis of 2-Phenyl- and 2,2-Diarylpyrrolidines through Stevens Rearrangement Performed on Azetidinium Ions". . p. 1103 - 1109. Retrieved 2015/10/05.