Oxilofrine

Base Information

• Chemical Name: Oxilofrine
• CAS No.: 365-26-4
• Deprecated CAS: 33987-39-2,34597-44-9
• Molecular Formula: C₁₀H₁₅NO₂
• Molecular Weight: 181.235
• European Community (EC) Number: 206-672-3
• UNII: F49638UBDR
• Nikkaji Number: J294.562B
• Wikipedia: Oxilofrine
• NCI Thesaurus Code: C74102
• Metabolomics Workbench ID: 152742
• ChEMBL ID: CHEMBL1160695
• Mol file: 365-26-4.mol

Synonyms:1-(4'-hydroxyphenyl)-2-methylaminopropanol;1-(4-hydroxyphenyl)-2-methylaminopropanol;4-hydroxyephedrine;carnigen;methylsynephrine;oxilofrin;oxilofrin, (R*,R*)-(+-)-isomer;oxilofrin, (R*,S*)-(+-)-isomer;oxilofrin, (R*,S*)-isomer;oxilofrin, (R-(R*,S*))-isomer;oxilofrin, hydrochloride;oxilofrin, hydrochloride, (R*,R*)-(+-)-isomer;oxilofrin, hydrochloride, (R*,S*)-(+-)-isomer;oxilofrin, hydrochloride, (R*,S*)-isomer;oxilofrine;oxilofrine hydrochloride;para-hydroxyephedrine;R-(-)-beta-O-methylsynephrine;suprifen

Chemical Property of Oxilofrine

Chemical Property:

• Vapor Pressure: 2.62E-05mmHg at 25°C
• Melting Point: 152-154°
• Refractive Index: 1.559
• Boiling Point: 343.8ºC at 760 mmHg
• PKA: 9.97±0.26(Predicted)
• Flash Point: 149.9ºC
• PSA: 52.49000
• Density: 1.124g/cm3
• LogP: 1.42440
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 181.110278721
• Heavy Atom Count: 13
• Complexity: 144

Purity/Quality:

99.9% ^*data from raw suppliers

Methylsynephrine Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C(C1=CC=C(C=C1)O)O)NC
• Isomeric SMILES: C[C@@H]([C@@H](C1=CC=C(C=C1)O)O)NC
• Therapeutic Function: Sympathomimetic, Analeptic

Technology Process of Oxilofrine

There total 5 articles about Oxilofrine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(4-hydroxy-phenyl)-2-methylamino-propan-1-one (132224-98-7) → oxilofrine (365-26-4,34597-44-9,52671-39-3,67381-70-8,85482-66-2,102680-48-8,102734-79-2)

Guidance literature:

With ethanol; nickel; at 100 ℃; under 29420.3 Torr; Hydrogenation;

Reference yield:

→ oxilofrine (365-26-4,34597-44-9,52671-39-3,67381-70-8,85482-66-2,102680-48-8,102734-79-2)

Guidance literature:

With hydrogenchloride; nickel; at 100 ℃; under 29420.3 Torr; Hydrogenation;

Reference yield:

→ oxilofrine (365-26-4,34597-44-9,52671-39-3,67381-70-8,85482-66-2,102680-48-8,102734-79-2)

Guidance literature:

With water; copper;

upstream raw materials:

1-(4-hydroxy-phenyl)-2-methylamino-propan-1-one

methylamine

Downstream raw materials:

4-methoxyphenylacetone