Piperidin-3-yl-pyrrolidin-1-yl-methanone

Base Information

• Chemical Name: Piperidin-3-yl-pyrrolidin-1-yl-methanone
• CAS No.: 86542-87-2
• Molecular Formula: C₁₀H₁₈N₂O
• Molecular Weight: 182.266
• Mol file: 86542-87-2.mol

Synonyms:Piperidin-3-yl-pyrrolidin-1-yl-methanone

Chemical Property of Piperidin-3-yl-pyrrolidin-1-yl-methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of Piperidin-3-yl-pyrrolidin-1-yl-methanone

There total 4 articles about Piperidin-3-yl-pyrrolidin-1-yl-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

→ 1-(piperidine-3-carbonyl)-pyrrolidine (35090-94-9,86542-87-2,86542-88-3)

Guidance literature:

Reference yield:

C15H26N2O3 (937724-78-2) → 1-(piperidine-3-carbonyl)-pyrrolidine (35090-94-9,86542-87-2,86542-88-3)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane;

DOI:10.1016/j.bmcl.2007.01.094

Reference yield:

N-(tert-butyloxycarbonyl)nipecotic acid (71381-75-4,88495-54-9,84358-12-3) → 1-(piperidine-3-carbonyl)-pyrrolidine (35090-94-9,86542-87-2,86542-88-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / 1-ethyl-3-(dimethylaminopropyl)carbodiimide*HCl; 1-hydroxybenzotriazole / CH₂Cl₂ / 20 °C

2: HCl / dioxane

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; dichloromethane;

DOI:10.1016/j.bmcl.2007.01.094

upstream raw materials:

C₁₅H₂₆N₂O₃

N-(tert-butyloxycarbonyl)nipecotic acid

nipecotic acid

Downstream raw materials:

C₂₈H₃₆F₃N₅O₂

N-(2-Cyano-4,5-dimethoxy-phenyl)-3-(pyrrolidine-1-carbonyl)-piperidine-1-carboximidothioic acid methyl ester

3-(Pyrrolidine-1-carbonyl)-piperidine-1-carbothioic acid (2-cyano-4,5-dimethoxy-phenyl)-amide

Refernces

• 1、 -. "INHIBITORS OF BIOFILM FORMATION OF GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA". Page/Page column 67-68. . Retrieved 2009/07/18.