2-Methyl-3-nitropyridine N-oxide

Base Information

• Chemical Name: 2-Methyl-3-nitropyridine N-oxide
• CAS No.: 5236-76-0
• Molecular Formula: C6H6 N2 O3
• Molecular Weight: 154.125
• Hs Code.: 2933399090
• Mol file: 5236-76-0.mol

Synonyms:2-Picoline,3-nitro-, 1-oxide (7CI,8CI); 2-Methyl-3-nitropyridine 1-oxide;2-Methyl-3-nitropyridine N-oxide

Chemical Property of 2-Methyl-3-nitropyridine N-oxide

Chemical Property:

• Vapor Pressure: 1.87E-10mmHg at 25°C
• Boiling Point: 490.9°Cat760mmHg
• Flash Point: 250.7°C
• PSA: 99.17000
• Density: 1.477g/cm³
• LogP: 3.74440

Purity/Quality:

99% ^*data from raw suppliers

2-Methyl-3-nitropyridine N-oxide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Methyl-3-nitropyridine N-oxide

There total 7 articles about 2-Methyl-3-nitropyridine N-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2-methyl-3-nitropyridine (18699-87-1) → 2-methyl-3-nitropyridine 1-oxide (5236-76-0)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 6h;

Reference yield:

diethyl 2-(3-nitropyridin-2-yl)malonate (64362-41-0) → 2-methyl-3-nitropyridine 1-oxide (5236-76-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / Heating

2: carbamide peroxide; trifluoroacetic anhydride / dichloromethane / 0 - 20 °C

With sulfuric acid; carbamide peroxide; trifluoroacetic anhydride; In dichloromethane;

DOI:10.1021/ol202597b

Reference yield:

2,6-dimethylpyridine (108-48-5) → 2-methyl-3-nitropyridine 1-oxide (5236-76-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 90 percent / HNO₃, H₂SO₄

2: 61 percent / SeO₂, KMnO₄

3: 97 percent / decarboxylation

4: 66 percent / 30percent H₂O₂ / acetic acid; benzene

With potassium permanganate; selenium(IV) oxide; sulfuric acid; dihydrogen peroxide; nitric acid; In acetic acid; benzene;

DOI:10.1016/S0040-4039(00)93168-X

upstream raw materials:

2-methylpyridine N-oxide

2-methyl-3-nitropyridine

2,6-dimethylpyridine

3-nitro-2,6-lutidine

Downstream raw materials:

3-nitropyridine N-oxide

6-cyclohexyl-2-methyl-3-nitropyridine-1-oxide

2-methyl-3-nitro-6-p-tolylpyridine-1-oxide

2-methyl-3-nitro-6-phenylpyridine-1-oxide

Refernces

• 1、 -. "Bicyclic And Tricyclic Compounds As KAT II Inhibitors". Page/Page column 32-33. . Retrieved 2010/12/31.
• 2、 Achremowicz, Lucjan. "OXIDATIVE DEMETHYLATION OF SOME METHYLNITROPYRIDINE 1-OXIDES". . p. 2433 - 2434. Retrieved 2007/10/02.