3,3-Diphenylpropionic Acid Ethyl Ester

Base Information

• Chemical Name: 3,3-Diphenylpropionic Acid Ethyl Ester
• CAS No.: 7476-18-8
• Molecular Formula: C17H18O2
• Molecular Weight: 254.329
• Hs Code.: 2916399090
• Mol file: 7476-18-8.mol

Synonyms:Propionicacid, 3,3-diphenyl-, ethyl ester (8CI);Ethyl 3,3-diphenylpropionate;NSC401896;

Chemical Property of 3,3-Diphenylpropionic Acid Ethyl Ester

Chemical Property:

• Vapor Pressure: 3.1E-05mmHg at 25°C
• Refractive Index: 1.547
• Boiling Point: 355.6 °C at 760 mmHg
• Flash Point: 133.1 °C
• PSA: 26.30000
• Density: 1.063 g/cm³
• LogP: 3.77170

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,3-Diphenylpropionic Acid Ethyl Ester

There total 32 articles about 3,3-Diphenylpropionic Acid Ethyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

phenyldimethylsilyl chloride (768-33-2) + ethyl cinnamate (4192-77-2) → 3,3-diphenyl-propionic acid ethyl ester (7476-18-8)

Guidance literature:

phenyldimethylsilyl chloride; With potassium carbonate; In toluene; at 20 ℃; for 2h;

ethyl cinnamate; With water; [Rh(OH)(cod)]2; In toluene; at 120 ℃; for 24h;

DOI:10.1055/s-2002-19787

Reference yield: 97.0%

ethyl cinnamate (4192-77-2) + dichloromethylphenylsilane (149-74-6) → 3,3-diphenyl-propionic acid ethyl ester (7476-18-8)

Guidance literature:

dichloromethylphenylsilane; With potassium carbonate; In toluene; at 20 ℃; for 2h;

ethyl cinnamate; With water; [Rh(OH)(cod)]2; In toluene; at 120 ℃; for 41h;

DOI:10.1055/s-2002-19787

Reference yield: 96.0%

ethyl cinnamate (4192-77-2) + phenylboronic acid (98-80-6) → 3,3-diphenyl-propionic acid ethyl ester (7476-18-8)

Guidance literature:

With acetic acid; [2,2]bipyridinyl; palladium diacetate; In tetrahydrofuran; water; at 40 ℃; for 72h;

DOI:10.1021/jo051561h

upstream raw materials:

ethanol

3,3-Diphenylpropionic acid

ethyl 3,3-diphenylacrylate

ethyl 3-hydroxy-3,3-diphenylpropanoate

Downstream raw materials:

3,3-Diphenylpropionic acid

3,3-diphenylpropanal

(3,3-diphenyl-propyl)-(2-morpholin-4-yl-ethyl)-amine

Refernces

• 1、 Zimmermann, Birte M.,Kobosil, Sarah C. K.,Teichert, Johannes F.. "Catalytic hydrogenation of α,β-unsaturated carboxylic acid derivatives using copper(i)/N-heterocyclic carbene complexes". supporting information. p. 2293 - 2296. Retrieved 2019/02/27.
• 2、 Chaudhary, Sandeep,Naikade, Niraj K.,Tiwari, Mohit K.,Yadav, Lalit,Shyamlal, Bharti Rajesh K.,Puri, Sunil K.. "New orally active diphenylmethyl-based ester analogues of dihydroartemisinin: Synthesis and antimalarial assessment against multidrug-resistant Plasmodium yoelii nigeriensis in mice". . p. 1536 - 1541. Retrieved 2016/07/27.