Trihexyphenidyl

Base Information

• Chemical Name: Trihexyphenidyl
• CAS No.: 144-11-6
• Molecular Formula: C20H31NO
• Molecular Weight: 301.472
• Hs Code.: 2933399090
• European Community (EC) Number: 205-614-4
• NSC Number: 12268
• UNII: 6RC5V8B7PO
• DSSTox Substance ID: DTXSID4023705
• Nikkaji Number: J19.358E,J5.826B
• Wikipedia: Trihexyphenidyl
• Wikidata: Q2991856
• NCI Thesaurus Code: C61988
• RXCUI: 10811
• Pharos Ligand ID: T26WWR711LGY
• Metabolomics Workbench ID: 42744
• ChEMBL ID: CHEMBL1490
• Mol file: 144-11-6.mol

Synonyms:Apo Trihex;Apo-Trihex;ApoTrihex;Artane;Benzhexol;Cyclodol;Hipokinon;Parkinane;Parkopan;Trihexane;Trihexidyl Hydrochloride;Trihexyphenidyl;Trihexyphenidyl Hydrochloride;Trihexyphenidyl Hydrochloride Elixir

Chemical Property of Trihexyphenidyl

Chemical Property:

• Vapor Pressure: 8.34E-09mmHg at 25°C
• Melting Point: 258.5 °C
• Refractive Index: 1.546
• Boiling Point: 447.852 °C at 760 mmHg
• PKA: 14.31±0.29(Predicted)
• Flash Point: 210.982 °C
• PSA: 23.47000
• Density: 1.041 g/cm³
• LogP: 4.26840
• XLogP3: 4.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 301.240564612
• Heavy Atom Count: 22
• Complexity: 314

Purity/Quality:

99.9% ^*data from raw suppliers

TRIHEXYPHENIDYL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Drug Classes: Antiparkinson Agents
• Canonical SMILES: C1CCC(CC1)C(CCN2CCCCC2)(C3=CC=CC=C3)O
• Recent ClinicalTrials: Childhood Hypertonia of Central Origin: A Trial of Anticholinergic Treatment Effects
• Uses: Trihexyphenidyl, an antiparkinsonian drug, possesses central and peripheral anticholinergic actions, as well as a direct relaxant effect on smooth muscle. It reduces muscle rigidity and general stiffness, and has a relatively minor effect on tremors. It is used in Parkinsonism in the form of monotherapy as well as in combination with levodopa. Anticholinergic; antiparkinsonian.
• Therapeutic Function: Antiparkinsonian

Technology Process of Trihexyphenidyl

There total 10 articles about Trihexyphenidyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-phenyl-3-(piperidin-1-yl)propan-1-one (73-63-2) + cyclohexylmagnesium bromide (931-50-0) → trihexyphenidyl (144-11-6)

Guidance literature:

With diethyl ether;

DOI:10.1021/ja01174a043 DOI:10.1021/ja01158a018

Reference yield:

1-cyclohexyl-3-piperidino-propan-1-one (30257-63-7) + phenylmagnesium bromide → trihexyphenidyl (144-11-6)

Guidance literature:

With diethyl ether;

Reference yield:

piperidine (110-89-4) → trihexyphenidyl (144-11-6)

Guidance literature:

Multi-step reaction with 2 steps

2: benzene

With benzene;

DOI:10.1002/ardp.19582910107

upstream raw materials:

1-cyclohexyl-3-piperidino-propan-1-one

1-phenyl-3-(piperidin-1-yl)propan-1-one

cyclohexylmagnesium bromide

Pridinol

Downstream raw materials:

1-(3-cyclohex-1-enyl-3-phenyl-propyl)-piperidine

(+)-Trihexyphenidyl

(-)-Trihexyphenidyl

1-(3ξ-cyclohexyl-3ξ-phenyl-allyl)-piperidine

Refernces

• 1、 -. "Pharmaceutical compositions and methods for preventing, treating, or reversing neuronal dysfunction". . . Retrieved 2009/03/07.
• 2、 -. "Aryl-cycloalkyl-alkanolamines for treatment of neurotoxic injury". . . Retrieved 2008/06/13.