(S)-(-)-Methyl-3,4-dihydro-6,7-dihydroxy-1'-methylspiro<1H-2-benzopyran-1,4'-piperidin>-3-carboxylat

Base Information

• Chemical Name: (S)-(-)-Methyl-3,4-dihydro-6,7-dihydroxy-1'-methylspiro<1H-2-benzopyran-1,4'-piperidin>-3-carboxylat
• CAS No.: 136749-57-0
• Molecular Formula: C₁₆H₂₁NO₅
• Molecular Weight: 307.346
• Mol file: 136749-57-0.mol

Synonyms:(S)-(-)-Methyl-3,4-dihydro-6,7-dihydroxy-1'-methylspiro<1H-2-benzopyran-1,4'-piperidin>-3-carboxylat

Chemical Property of (S)-(-)-Methyl-3,4-dihydro-6,7-dihydroxy-1'-methylspiro<1H-2-benzopyran-1,4'-piperidin>-3-carboxylat

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-(-)-Methyl-3,4-dihydro-6,7-dihydroxy-1'-methylspiro<1H-2-benzopyran-1,4'-piperidin>-3-carboxylat

There total 1 articles about (S)-(-)-Methyl-3,4-dihydro-6,7-dihydroxy-1'-methylspiro<1H-2-benzopyran-1,4'-piperidin>-3-carboxylat which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-3-(3-acetyl-4-hydroxyphenyl)-2-aminopropanoic acid hydrochloride (32404-28-7) → (S)-(-)-Methyl-3,4-dihydro-6,7-dihydroxy-1'-methylspiro<1H-2-benzopyran-1,4'-piperidin>-3-carboxylat (136749-57-0)

Guidance literature:

Multi-step reaction with 5 steps

1: NaNO₂ / H₂O / 24 h / Ambient temperature

2: CHCl₃ / 12 h / Heating; strongly acidic ion exchanger

3: 5 N NaOH, 30percent H₂O₂ / H₂O / 0.5 h / 40 °C

4: HCl-gas / 12 h / Heating

5: p-TsOH / 1,2-dichloro-ethane / 48 h / Heating

With hydrogenchloride; sodium hydroxide; dihydrogen peroxide; toluene-4-sulfonic acid; sodium nitrite; In chloroform; water; 1,2-dichloro-ethane;

upstream raw materials:

(S)-3-(3-acetyl-4-hydroxyphenyl)-2-aminopropanoic acid hydrochloride

Refernces