3,5-Dichloro-2-pyridinecarboxylic acid

Base Information

• Chemical Name: 3,5-Dichloro-2-pyridinecarboxylic acid
• CAS No.: 81719-53-1
• Molecular Formula: C6H3Cl2NO2
• Molecular Weight: 192.001
• Hs Code.: 2933399090
• Mol file: 81719-53-1.mol

Synonyms:3,5-Dichloropicolinic acid;NSC2010;3,5-Dichloro-2-picolinicacid;

Chemical Property of 3,5-Dichloro-2-pyridinecarboxylic acid

Chemical Property:

• Appearance/Colour: light yellow to white crystal
• Vapor Pressure: 0.000185mmHg at 25°C
• Melting Point: 153-154 °C
• Refractive Index: 1.605
• Boiling Point: 315.4 °C at 760 mmHg
• PKA: 2.12±0.25(Predicted)
• Flash Point: 144.6 °C
• PSA: 50.19000
• Density: 1.612 g/cm³
• LogP: 2.08660
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

3,5-Dichloro-2-pyridinecarboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-Dichloro-2-pyridinecarboxylic acid

There total 2 articles about 3,5-Dichloro-2-pyridinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-Cyano-3,5-dichloropyridine (85331-33-5) → 3,5-dichloropyridine-2-carboxylic acid (81719-53-1)

Guidance literature:

With sulfuric acid; water; at 115 ℃;

Reference yield:

3,4,5-trichloropicolinic acid (5439-04-3) + hydrogen iodide (10034-85-2) → 3,5-dichloropyridine-2-carboxylic acid (81719-53-1) + 3,5-dichloropyridine (2457-47-8)

Guidance literature:

Reference yield: 82.0%

3,5-dichloropyridine-2-carboxylic acid (81719-53-1) + (R)-4-(5-amino-2-fluorophenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine (1310350-45-8) → 3,5-dichloro-pyridine-2-carboxylic acid [3-((R)-2-amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide (1310347-44-4)

Guidance literature:

3,5-dichloropyridine-2-carboxylic acid; With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In methanol; at 0 ℃; for 0.5h;

(R)-4-(5-amino-2-fluorophenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine; In methanol; at 0 - 22 ℃; for 20h;

DOI:10.1021/jm400225m

upstream raw materials:

3,4,5-trichloropicolinic acid

hydrogen iodide

2-Cyano-3,5-dichloropyridine

Downstream raw materials:

3,5-dichloropyridine

methyl 3,5-dichloropicolinic acid chloride

methyl 3,5-dichloropyridine-2-carboxylate

C₃₆H₂₅Cl₂FN₄O₃S

Refernces