3-CHLORO-N-METHYLANILINE

Base Information

• Chemical Name: 3-CHLORO-N-METHYLANILINE
• CAS No.: 7006-52-2
• Molecular Formula: C7H8ClN
• Molecular Weight: 141.6
• Hs Code.: 29214200
• Mol file: 7006-52-2.mol

Synonyms:Aniline,m-chloro-N-methyl- (6CI,7CI,8CI);(3-Chlorophenyl)methylamine;3-Chloro-N-methylaniline;3-Chloro-N-methylbenzenamine;N-(3-Chlorophenyl)-N-methylamine;N-(3-Chlorophenyl)methylamine;N-Methyl-3-chloroaniline;N-Methyl-3-chloroaniline;N-Methyl-m-chloroaniline;

Chemical Property of 3-CHLORO-N-METHYLANILINE

Chemical Property:

• Appearance/Colour: clear yellow to brown liquid
• Vapor Pressure: 0.0513mmHg at 25°C
• Refractive Index: n20/D 1.5840(lit.)
• Boiling Point: 235 °C at 760 mmHg
• PKA: 4.05±0.25(Predicted)
• Flash Point: 93.8 °C
• PSA: 12.03000
• Density: 1.171 g/cm³
• LogP: 2.45470
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Chloro-N-methylaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi, Xn
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-36-36/37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: N-Methyl-3-chloroaniline may be used as a starting material in the preparation of:2N-(2-bromoethyl)-N-methyl-3-chloroaniline2-[2-(N-methyl-3-chloroanilino)ethyl]-1,3-isoindolinedioneN1-(3-chlorophenyl)-N1-methyl-1,2-ethanediamine dihydrochloride

Technology Process of 3-CHLORO-N-METHYLANILINE

There total 38 articles about 3-CHLORO-N-METHYLANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-bromo-3-chlorobenzene (108-37-2) + methylamine (74-89-5) → 3-chloro-N-methylaniline (7006-52-2)

Guidance literature:

With copper; In water; at 100 ℃; for 12h;

DOI:10.1021/jo102169t

Reference yield: 96.0%

methanol (67-56-1) + 3-chloro-aniline (108-42-9) → 3-chloro-N-methylaniline (7006-52-2)

Guidance literature:

With C₁₉H₃₇IrN₄⁽²⁺⁾*2I^(1-); potassium carbonate; at 120 ℃; for 17h; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1055/s-0037-1610252

Reference yield: 94.0%

m-chloroformanilide (139-71-9) → 3-chloro-N-methylaniline (7006-52-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; Ambient temperature;

DOI:10.1021/jm00014a014

upstream raw materials:

N-(3-chlorophenyl)-N-methylcyanamide

3-chloro-aniline

methyl iodide

N-(3-chlorobenzylidene)aniline

Downstream raw materials:

2-((3-chlorophenyl)(methyl)amino)ethan-1-ol

N-(3-chlorophenyl)-N-methylcarbamoyl chloride

3-chloro-N-methyl-4-nitroso-aniline

N-(3-chloro-phenyl)-N-methyl-N'-phenyl-urea

Refernces

• 1、 Illam, Praseetha Mathoor,Rit, Arnab. "Electronically tuneable orthometalated RuII–NHC complexes as efficient catalysts for C–C and C–N bond formations via borrowing hydrogen strategy". . p. 67 - 74. Retrieved 2022/01/19.
• 2、 -. "Method for realizing N-alkylation by using alcohols as carbon source under photocatalysis". Paragraph 0048-0056; 0058. . Retrieved 2021/03/13.