2-PHENYLTHIAZOLE

Base Information

• Chemical Name: 2-PHENYLTHIAZOLE
• CAS No.: 1826-11-5
• Molecular Formula: C9H7NS
• Molecular Weight: 161.227
• Hs Code.: 2934100090
• Mol file: 1826-11-5.mol

Synonyms:2-Phenyl-1,3-thiazole;2-Phenylthiazole;

Chemical Property of 2-PHENYLTHIAZOLE

Chemical Property:

• Vapor Pressure: 0.00765mmHg at 25°C
• Melting Point: 114 °C
• Refractive Index: 1.604
• Boiling Point: 277.402 °C at 760 mmHg
• PKA: 2.43±0.10(Predicted)
• Flash Point: 126.74 °C
• PSA: 41.13000
• Density: 1.173 g/cm₃
• LogP: 2.81010
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Phenylthiazole 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-PHENYLTHIAZOLE

There total 55 articles about 2-PHENYLTHIAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-chloroethanal (107-20-0) + benzenecarbothioamide (2227-79-4) → 2-phenylthiazole (1826-11-5)

Guidance literature:

In ethanol; at 95 ℃; for 3h;

DOI:10.1002/asia.201500328

Reference yield: 97.0%

benzenecarbothioamide (2227-79-4) + Bromoacetaldehyde diethyl acetal (2032-35-1) → 2-phenylthiazole (1826-11-5)

Guidance literature:

With toluene-4-sulfonic acid; In ethanol; water; at 100 ℃; for 16h; Inert atmosphere;

DOI:10.1002/chem.201605511

Reference yield: 95.0%

4-bromo-2-phenylthiazole (141305-40-0) → 2-phenylthiazole (1826-11-5)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium tetrahydroborate; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; at 25 ℃; for 30h; Reagent/catalyst; Inert atmosphere;

DOI:10.1016/j.molcata.2014.06.012

upstream raw materials:

piperidine

ethanol

benzenecarbothioamide

bromoacetaldehyde

Downstream raw materials:

5-phenyl-thiazolo[3,2-a]pyridine-6,7,8,8a-tetracarboxylic acid tetramethyl ester

4-phenyl-thiazole

3-phenylisothiazole

5-iodo-2-phenylthiazole

Refernces

• 1、 Allouch, Fatima,Vologdin, Nikolay V.,Cattey, Hélène,Pirio, Nadine,Naoufal, Daoud,Kanj, Ali,Smaliy, Radomyr V.,Savateev, Aleksandr,Marchenko, Anatoly,Hurieva, Anastasia,Koidan, Heorgii,Kostyuk, Aleksandr N.,Hierso, Jean-Cyrille. "Ferrocenyl (P,N)-diphosphines incorporating pyrrolyl, imidazolyl or benzazaphospholyl moieties: Synthesis, coordination to group 10 metals and performances in palladium-catalyzed arylation reactions". . p. 38 - 46. Retrieved 2013.
• 2、 Ahmed, Jasimuddin,Datta, Paramita,Das, Arpan,Jomy, Stephy,Mandal, Swadhin K.. "Switching between mono and doubly reduced odd alternant hydrocarbon: designing a redox catalyst". . p. 3039 - 3049. Retrieved 2021/03/14.
• 3、 Kolmar, Theresa,Becker, Antonia,Pfretzschner, Ronja A.,Lelke, Alina,J?schke, Andres. "Development of Red-Shifted and Fluorogenic Nucleoside and Oligonucleotide Diarylethene Photoswitches". supporting information. p. 17386 - 17394. Retrieved 2021/10/20.