5-Bromo-1,3-difluoro-2-nitrobenzene

Base Information

• Chemical Name: 5-Bromo-1,3-difluoro-2-nitrobenzene
• CAS No.: 147808-42-2
• Molecular Formula: C6H2BrF2NO2
• Molecular Weight: 237.988
• Hs Code.: 2904909090
• Mol file: 147808-42-2.mol

Synonyms:5-Bromo-1,3-difluoro-2-nitrobenzene;

Chemical Property of 5-Bromo-1,3-difluoro-2-nitrobenzene

Chemical Property:

• Vapor Pressure: 0.0148mmHg at 25°C
• Refractive Index: 1.556
• Boiling Point: 265.7 °C at 760 mmHg
• Flash Point: 114.5 °C
• PSA: 45.82000
• Density: 1.890g/cm³
• LogP: 3.15870
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Bromo-1,3-difluoro-2-nitrobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Bromo-1,3-difluoro-2-nitrobenzene

There total 4 articles about 5-Bromo-1,3-difluoro-2-nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

4-bromo-2,6-difluoroaniline (67567-26-4) → 5-bromo-1,3-difluoro-2-nitro-benzene (147808-42-2)

Guidance literature:

With sodium perborate; acetic acid; at 65 - 70 ℃; for 21h; Inert atmosphere;

DOI:10.1021/jm300069y

Reference yield:

4-amino-2,6-difluoronitrobenzene (122129-79-7) → 5-bromo-1,3-difluoro-2-nitro-benzene (147808-42-2)

Guidance literature:

With hydrogen bromide; copper(I) bromide; sodium nitrite; Multistep reaction; 1.) 0 deg C, 2.) 3 h;

Reference yield:

2,6-difluoroaniline (5509-65-9) → 5-bromo-1,3-difluoro-2-nitro-benzene (147808-42-2)

Guidance literature:

Multi-step reaction with 2 steps

1: bromine; acetic acid / 2 h / 20 °C / Cooling with ice

2: acetic acid; sodium peroxoborate tetrahydrate / 65 °C

With sodium peroxoborate tetrahydrate; bromine; acetic acid;

DOI:10.1016/j.ejmech.2015.10.028

upstream raw materials:

4-amino-2,6-difluoronitrobenzene

4-bromo-2,6-difluoroaniline

2,6-difluoroaniline

Downstream raw materials:

C₁₀H₁₂BrFN₂O₃

C₁₁H₁₅BrFN₃O₂

Refernces

• 1、 -. "Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders". Page/Page column 51; 52. . Retrieved 2017/01/09.
• 2、 -. "BENZIMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS". Paragraph 00237. . Retrieved 2015/08/06.