3,4-Difluoro-2-methoxybenzoic acid

Base Information

• Chemical Name: 3,4-Difluoro-2-methoxybenzoic acid
• CAS No.: 875664-52-1
• Molecular Formula: C₈H₆F₂O₃
• Molecular Weight: 188.131
• Hs Code.: 2918990090
• Mol file: 875664-52-1.mol

Synonyms:3,4-DIFLUORO-2-METHOXYBENZOIC ACID;3,4-Difluoro-2-methoxyBenzoicacid98+%;3,4-Difluoro-2-methoxybenzoic acid 97+%

Chemical Property of 3,4-Difluoro-2-methoxybenzoic acid

Chemical Property:

• Appearance/Colour: liquid
• Vapor Pressure: 0.00707mmHg at 25°C
• Melting Point: 137-139ºC
• Boiling Point: 276.9 °C at 760 mmHg
• PKA: 3.69±0.10(Predicted)
• Flash Point: 121 ºC
• PSA: 46.53000
• Density: 1.399
• LogP: 1.67160
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

3,4-Difluoro-2-methoxybenzoicacid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,T
• Statements: 36/37/38-25
• Safety Statements: 26-37-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,4-Difluoro-2-methoxybenzoic acid

There total 2 articles about 3,4-Difluoro-2-methoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methanol (67-56-1) + 2,3,4,-trifluorobenzoic acid (61079-72-9) → 2-methoxy-3,4-difluorobenzoic acid (875664-52-1)

Guidance literature:

methanol; With iodine; magnesium; In diethylene glycol dimethyl ether; Reflux;

2,3,4,-trifluorobenzoic acid; In diethylene glycol dimethyl ether; at 85 - 90 ℃; for 2h;

DOI:10.1016/j.bmcl.2016.03.107

Reference yield:

magnesium methanolate (109-88-6,16436-83-2,16436-85-4) + 2,3,4,-trifluorobenzoic acid (61079-72-9) → 2-methoxy-3,4-difluorobenzoic acid (875664-52-1)

Guidance literature:

regioselective reaction; Reflux;

DOI:10.1016/j.bmc.2016.10.014

Reference yield:

2-methoxy-3,4-difluorobenzoic acid (875664-52-1) → 2-acetyloxy-3,4-difluorobenzoic acid

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen bromide; water / 70 °C

2: sulfuric acid / Reflux

With sulfuric acid; water; hydrogen bromide;

DOI:10.1016/j.bmc.2016.10.014

upstream raw materials:

methanol

2,3,4,-trifluorobenzoic acid

magnesium methanolate

Refernces

• 1、 Shchegol'Kov, Evgeny V.,Shchur, Irina V.,Burgart, Yanina V.,Saloutin, Victor I.,Solodnikov, Sergey Yu.,Krasnykh, Olga P.,Kravchenko, Marionella A.. "A convenient and efficient approach to polyfluorosalicylic acids and their tuberculostatic activity". supporting information. p. 2455 - 2458. Retrieved 2016/07/07.