Isopropyl Myristate

Base Information Edit

Chemical Name:Isopropyl Myristate
CAS No.:110-27-0
Deprecated CAS:1405-98-7,852553-53-8,852553-53-8
Molecular Formula:C17H34O2
Molecular Weight:270.456
Hs Code.:29159080
European Community (EC) Number:203-751-4
NSC Number:406280
UNII:0RE8K4LNJS
DSSTox Substance ID:DTXSID0026838
Nikkaji Number:J10.110I
Wikipedia:Isopropyl_myristate
Wikidata:Q416222
NCI Thesaurus Code:C76717
RXCUI:27985
Metabolomics Workbench ID:4322
ChEMBL ID:CHEMBL207602
Mol file:110-27-0.mol

Synonyms:isopropyl myristate;isopropylmyristate

Suppliers and Price of Isopropyl Myristate

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Isopropyl Myristate
25g
$ 130.00

TCI Chemical
Isopropyl Myristate >98.0%(GC)
25mL
$ 25.00

TCI Chemical
Isopropyl Myristate >98.0%(GC)
500mL
$ 62.00

Sigma-Aldrich
Isopropyl Myristate ≥98%
20 kg
$ 615.00

Sigma-Aldrich
Isopropyl Myristate ≥98%
20kg-k
$ 615.00

Sigma-Aldrich
Isopropyl myristate United States Pharmacopeia (USP) Reference Standard
500mg
$ 399.00

Sigma-Aldrich
Isopropyl myristate for synthesis
25 kg
$ 1570.00

Sigma-Aldrich
Isopropyl myristate for synthesis. CAS 110-27-0, molar mass 270.45 g/mol., for synthesis
8221029025
$ 1520.00

Sigma-Aldrich
Isopropyl myristate ≥90% (GC)
1l
$ 142.00

Sigma-Aldrich
Isopropyl myristate Pharmaceutical Secondary Standard; Certified Reference Material
1g
$ 72.80

Total 222 raw suppliers

Chemical Property of Isopropyl Myristate Edit

Chemical Property:

Appearance/Colour:colourless liquid of low viscosity
Vapor Pressure:0.000329mmHg at 25°C
Melting Point:-5 °C
Refractive Index:n20/D 1.434(lit.)
Boiling Point:319.9 °C at 760 mmHg
Flash Point:144.1 °C
PSA：26.30000
Density:0.864 g/cm³
LogP:5.63910
Storage Temp.:2-8°C
Solubility.:<0.05mg/l
Water Solubility.:Miscible with alcohol. Immiscible with water and glycerol.
XLogP3:7.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:14
Exact Mass:270.255880323
Heavy Atom Count:19
Complexity:199

Purity/Quality:

99%, ^*data from raw suppliers

Isopropyl Myristate ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Chemical Classes:Other Uses -> Emulsifiers/Surfactants
Canonical SMILES:CCCCCCCCCCCCCC(=O)OC(C)C
Recent EU Clinical Trials:Randomised, double-blind, bilateral comparison of two emollients in patients with dry skin
Uses Isopropyl myristate (IPM) is a fatty acid ester which is used as solvent in water-in-oil emulsion, oils and fatty based ointments. The use of IPM is recommended in the Sterility Test chapter of the European, Japanese and United States Pharmacopoeia (EP, 2.6.13, JP, 4.06 and USP, 71) as diluent for oils and oily solutions, as well as for ointments and creams. Indeed, its solvent properties improve the filterability of these samples.Isopropyl myristate is known as a penetration enhancer for topical preparations. It is a waterclear, low viscous oily liquid with a very good spreading capacity on the skin. Isopropyl Myristate is mainly used in cosmetics as an oilcomponent for emulsions, bath oils and as a solvent for active substances. Isopropyl myristate is an emollient in cosmetic and pharmaceutical bases. In cosmetic and topical medicinal Preparations where good absorption through the skin is desired. A jellied isopropyl myristate was marketed as Estergel (Merck & Co.) . isopropyl myristate is an emollient, moisturizer, binder, and skin softener that also assists in product penetration. An ester of myristic acid, it is naturally occurring in coconut oil and nutmeg. Although isopropyl myristate is generally considered comedogenic, some ingredient manufacturers clearly specify non-comedogenicity on their data sheets.
Production Method It is a product of esterification of myristic acid derived from re-steamed coconut coil with isopropyl alcohol. (1)? 200 kg myristic acid and 450 kg isopropyl alcohol were added into the reaction vessel in turn. After mixing, 360 kg sulfuric acid (98%) was added. The reaction mixture was heated to reflux for 10 hours. Isopropyl alcohol was then recovered, washed with ice water, and neutralized with Na2CO3 aqueous solution (10%). Under normal pressure, isopropyl alcohol and water were distilled. While under reduced pressure, isopropyl myristate was distilled (185°C/1.0kPa~195°C/2.7kPa). (2) 90 kg isopropyl alcohol was added into the reaction vessel and then sulfuric acid as catalyst, with 5% of the total amount, was added. During mixing, 228 kg myristic acid was added slowly. The mixture was heated to reflux and water was continuously separated. Until no water was separated, the reaction temperature was reduced and probe was obtained to measure the acid value. When the acid value reached 1.5 mg KOH/g, the reaction was completed. Alkali was then added for neutralization. After the removal of water under reduced pressure, the pressure was further reduced for dealcoholization until the acid value was 0.05~1.0 mg KOH/g. The final product is then isopropyl myristate.
Description Isopropyl myristate is odorless when pure. May be synthesized by conventional esterification of isopropanol with myristic acid.

Technology Process of Isopropyl Myristate

There total 5 articles about Isopropyl Myristate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.5%