1-[2-[(4-Chlorophenyl)-phenylmethoxy]ethyl]piperidine;hydron;chloride

Base Information

• Chemical Name: 1-[2-[(4-Chlorophenyl)-phenylmethoxy]ethyl]piperidine;hydron;chloride
• CAS No.: 14984-68-0
• Molecular Formula: C20H24ClNO^.HCl
• Molecular Weight: 366.331
• Hs Code.: 2933399090
• Mol file: 14984-68-0.mol

Synonyms:AKOS015900932

Chemical Property of 1-[2-[(4-Chlorophenyl)-phenylmethoxy]ethyl]piperidine;hydron;chloride

Chemical Property:

• Vapor Pressure: 2.15E-07mmHg at 25°C
• Melting Point: 147.9°
• Boiling Point: 423.9 °C at 760 mmHg
• Flash Point: 210.2 °C
• PSA: 12.47000
• LogP: 5.67180
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 365.1313198
• Heavy Atom Count: 24
• Complexity: 318

Purity/Quality:

99% ^*data from raw suppliers

Cloperastine Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: [H+].C1CCN(CC1)CCOC(C2=CC=CC=C2)C3=CC=C(C=C3)Cl.[Cl-]
• Uses: Antitussive;'Histamine antagonist Cloperastine Hydrochloride is an anti-tussive drug as an over-the-counter cold medicine.

Technology Process of 1-[2-[(4-Chlorophenyl)-phenylmethoxy]ethyl]piperidine;hydron;chloride

There total 2 articles about 1-[2-[(4-Chlorophenyl)-phenylmethoxy]ethyl]piperidine;hydron;chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.2%

1-piperidinoethanol (3040-44-6) + 1-chloro-4-(chloro(phenyl)methyl)benzene (134-83-8,60035-71-4) → Cloperastine hydrochloride (14984-68-0)

Guidance literature:

1-piperidinoethanol; 1-chloro-4-(chloro(phenyl)methyl)benzene; With triethylamine; In dichloromethane; at 20 - 30 ℃; for 3h;

With hydrogenchloride; In Isopropyl acetate; at 20 - 30 ℃; for 1h; Solvent; Temperature; Reagent/catalyst;

Reference yield: 89.8%

2-(piperidin-4-yl)ethyl chloride (1932-03-2) + (4-chlorophenyl)phenylmethanol (119-56-2) → Cloperastine hydrochloride (14984-68-0)

Guidance literature:

2-(piperidin-4-yl)ethyl chloride; (4-chlorophenyl)phenylmethanol; With tetra-(n-butyl)ammonium iodide; triethylamine; In dichloromethane; at 30 - 40 ℃; for 5h;

With hydrogenchloride; In ethyl acetate; at 20 - 30 ℃; for 1h;

Reference yield: 93.0%

Cloperastine hydrochloride (14984-68-0) → 1-[2-[(4-chlorophenyl)phenylmethoxy]ethyl]piperidinone

Guidance literature:

With water; oxygen; sodium hydroxide; In tetrahydrofuran; at 60 ℃; for 24h; under 760.051 Torr; regioselective reaction; Green chemistry;

DOI:10.1002/anie.201602695

upstream raw materials:

1-piperidinoethanol

1-chloro-4-(chloro(phenyl)methyl)benzene

2-(piperidin-4-yl)ethyl chloride

(4-chlorophenyl)phenylmethanol

Refernces