Potassium oxonate

Base Information

• Chemical Name: Potassium oxonate
• CAS No.: 2207-75-2
• Deprecated CAS: 20636-38-8
• Molecular Formula: C4H2KN3O4
• Molecular Weight: 195.176
• Hs Code.: 29349990
• European Community (EC) Number: 218-627-5
• UNII: 4R7FFA00RX
• DSSTox Substance ID: DTXSID5046568
• Nikkaji Number: J42.695D
• Wikidata: Q27149343
• NCI Thesaurus Code: C2415
• ChEMBL ID: CHEMBL3184847
• Mol file: 2207-75-2.mol

Synonyms:potassium oxonate

Chemical Property of Potassium oxonate

Chemical Property:

• Appearance/Colour: off-white solid
• Melting Point: 300 °C(lit.)
• PSA: 118.74000
• LogP: -3.17830
• Storage Temp.: Refrigerator, Under Inert Atmosphere
• Solubility.: Aqueous Base (Slightly), Water (Slightly, Heated, Sonicated)
• Water Solubility.: Soluble in hot water.
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 194.96823704
• Heavy Atom Count: 12
• Complexity: 274

Purity/Quality:

99% ^*data from raw suppliers

NOX4 ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1(=NC(=O)NC(=O)N1)C(=O)[O-].[K+]
• Recent NIPH Clinical Trials: A phase II study of S-1 plus resminostat for biliary tract cancer
• Description: Oxonic acid is a uricase inhibitor that prevents metabolism and excretion of uric acid and induces embryotoxicity and nephrotoxicity in rats. It is a component of S-1, a mixture containing a prodrug of the antitumor agent 5-fluorouracil (5-FU; ), that suppresses the gastrointestinal toxicity of 5-FU without inhibiting its antitumor activity in rats. Formulations containing oxonic acid have been used to treat gastric, pancreatic, lung, head, neck, and breast carcinomas.
• Uses: Antitumor effect potentiator and antitumor agent Oxonic acid potassium salt is an inhibitor of uricase. The product from Sigma has been used for the inhibition of 5-fluorouracil-induced gastrointestinal toxicity without the loss of its antitumor activity in rats.It has also been used to induce hyperuricemia in rats; as it inhibits uric acid metabolism. Oxonic acid potassium salt is an inhibitor of uricase. The product from Sigma has been used for the inhibition of 5-fluorouracil-induced gastrointestinal toxicity without the loss of its antitumor activity in rats. It has also been used to induce hyperuricemia in rats; as it inhibits uric acid metabolism.

Technology Process of Potassium oxonate

There total 5 articles about Potassium oxonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.64%

oxaluric acid (585-05-7) + urea (57-13-6) → monopotassium 1,2,3,4-tetrahydro-2,4-dioxo-1,3,5-triazine-6-carboxylate (2207-75-2)

Guidance literature:

oxaluric acid; urea; With toluene-4-sulfonic acid; In ethanol; at 50 ℃; for 6h;

With potassium hydroxide; In ethanol; water; at 0 ℃; for 2h; pH=5.5; Temperature; Reagent/catalyst; Solvent; pH-value;

Reference yield: 91.32%

Allantoin (97-59-6) → monopotassium 1,2,3,4-tetrahydro-2,4-dioxo-1,3,5-triazine-6-carboxylate (2207-75-2)

Guidance literature:

With N-Bromosuccinimide; potassium iodide; potassium hydroxide; In water; at 0 - 25 ℃; for 3h; Temperature; Reagent/catalyst; Darkness;

Reference yield: 82.0%

dehydro-allantoin (105245-87-2) → monopotassium 1,2,3,4-tetrahydro-2,4-dioxo-1,3,5-triazine-6-carboxylate (2207-75-2)

Guidance literature:

With potassium hydroxide; In water; for 0.333333h;

DOI:10.1016/S0040-4020(01)87480-9

upstream raw materials:

dehydro-allantoin

acetic acid

Allantoin

oxaluric acid

Refernces

• 1、 -. "Preparation method of oteracil potassium". Paragraph 0040-0065. . Retrieved 2020/01/25.
• 2、 -. "Method for producing potassium oxonate". . . Retrieved 2008/06/13.