7-Methoxycoumarin

Base Information

• Chemical Name: 7-Methoxycoumarin
• CAS No.: 4003-89-8
• Molecular Formula: C11H15NO
• Molecular Weight: 177.25
• Mol file: 4003-89-8.mol

Synonyms:2H-1-Benzopyran-2-one, 7-methoxy-;7-Methoxy-2H-chromen-2-on;

Chemical Property of 7-Methoxycoumarin

Chemical Property:

• Melting Point: 218-220°C
• Boiling Point: 299.6±40.0 °C(Predicted)
• PKA: 10.21±0.20(Predicted)
• PSA: 39.44000
• Density: 1.056±0.06 g/cm3(Predicted)
• LogP: 1.80160
• Storage Temp.: -20°C Freezer
• Solubility.: Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

7-Methoxycoumarin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 7-Methoxycoumarin is a compound biosynthesized in lavender that exhibits antimicrobial activity. 7-Methoxycoumarin is also a natural component of key lime oils and is also used as an insecticide.

Technology Process of 7-Methoxycoumarin

There total 17 articles about 7-Methoxycoumarin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

7-methoxy-2-(trifluoroacetylamino)-1,2,3,4-tetrahydronaphthalene (1262722-83-7) → 2-amino-7-methoxy-1,2,3,4-tetrahydronaphthalene (4003-89-8,118298-16-1)

Guidance literature:

With water; potassium carbonate; In methanol; at 20 ℃; for 22.5h; Inert atmosphere;

DOI:10.1016/j.tet.2010.11.010

Reference yield: 92.0%

7-Methoxy-1,2,3,4-tetrahydro-(2R)-2-naphthaleneamine hydrochloride (3880-78-2,158223-16-6) → 2-amino-7-methoxy-1,2,3,4-tetrahydronaphthalene (4003-89-8,118298-16-1)

Guidance literature:

With sodium hydroxide; In water; ethyl acetate;

DOI:10.1021/jm101479y

Reference yield: 82.0%

N-benzyl-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine (83343-23-1) → 2-amino-7-methoxy-1,2,3,4-tetrahydronaphthalene (4003-89-8,118298-16-1)

Guidance literature:

With ammonium hydroxide; hydrogen; acetic acid; palladium(II) hydroxide; In ethanol; for 96h;

upstream raw materials:

2-amino-7-methoxynaphthalene

7-methoxy-3,4-dihydro-1H-naphthalen-2-one oxime

(1,2,3,4-tetrahydro-7-methoxy-2-naphthyl)hydrazine

benzyl (3aRS,9bSR)-N-(2,3,3a,4,5,9b-hexahydro-8-methoxy-2-oxonaphth<2.1-d>oxazol-3-yl)carbamate

Downstream raw materials:

4-fluoro-N-(7-methoxy-1,2,3,4-tetrahydronaphthalene-2-yl)-benzamide

N-(7-methoxy-1,2,3,4-tetrahydronaphth-2-yl)-2-hydroxy-3-[1-(p-toluenesulfonyl)indol-4-yloxy]propanamine hydrochloride

methyl 7-[(phenylsulfonyl)amino]-5,6,7,8-tetrahydronaphthalene-2-carboxylate

methyl 7-[(3-methoxyphenyl)amino]-5,6,7,8-tetrahydronaphthalene-2-carboxylate

Refernces

• 1、 -. "SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF". Page/Page column 60. . Retrieved 2012/02/01.
• 2、 -. "Novel aminotransferase, gene encoding the same, and method of using them". . . Retrieved 2010/12/29.