3-Fluoro-2-methoxyaniline

Base Information

• Chemical Name: 3-Fluoro-2-methoxyaniline
• CAS No.: 437-83-2
• Molecular Formula: C7H8FNO
• Molecular Weight: 141.145
• Hs Code.: 2922299090
• Mol file: 437-83-2.mol

Synonyms:o-Anisidine,3-fluoro- (8CI);2-Amino-6-fluoroanisole;3-Fluoro-2-methoxyaniline;3-Fluoro-2-methoxyphenylamine;

Chemical Property of 3-Fluoro-2-methoxyaniline

Chemical Property:

• Appearance/Colour: Brown crystal
• Vapor Pressure: 0.129mmHg at 25°C
• Melting Point: 162 °C
• Refractive Index: n20/D 1.446(lit.)
• Boiling Point: 217.9 °C at 760 mmHg
• PKA: 3.52±0.10(Predicted)
• Flash Point: 42.2 °C
• PSA: 35.25000
• Density: 1.176g/cm³
• LogP: 1.99770
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Fluoro-2-methoxyaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F; Xi
• Hazard Codes: F,Xi,T
• Statements: 11-36/37/38-24/25
• Safety Statements: 16-26-36-45-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Fluoro-2-methoxyaniline is a reactant in the synthesis of hydroxyquinolines.

Technology Process of 3-Fluoro-2-methoxyaniline

There total 8 articles about 3-Fluoro-2-methoxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-fluoro-2-methoxy-3-nitrobenzene (484-94-6) → 3-fluoro-2-methoxyaniline (437-83-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; for 24h;

Reference yield: 86.0%

bromo-4 fluoro-2 nitro-6 anisole (74266-66-3) → 3-fluoro-2-methoxyaniline (437-83-2)

Guidance literature:

With potassium hydroxide; hydrogen; palladium on activated charcoal; In methanol; for 1h; under 60004.8 - 75005.9 Torr;

Reference yield:

2-fluoro-6-nitrophenol (1526-17-6,34470-85-4) → 3-fluoro-2-methoxyaniline (437-83-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / dimethylformamide / 6 h / 80 °C

2: H₂ / Pd/C / methanol / 27 h / 20 °C

With hydrogen; potassium carbonate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm060844e

upstream raw materials:

1-fluoro-2-methoxy-3-nitrobenzene

bromo-4 fluoro-2 nitro-6 anisole

2-fluoro-6-nitrophenol

4-bromo-2-fluorophenol

Downstream raw materials:

1,3-difluoro-2-methoxybenzene

4-nitro-benzoic acid-(3-fluoro-2-methoxy-anilide)

fluoro-3 methoxy-2 benzaldehhyde

3-fluorosalicylaldehyde

Refernces

• 1、 -. "INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL". Page/Page column 54. . Retrieved 2014/09/03.
• 2、 Wang, Qiuping,Lucien, Edlaine,Hashimoto, Akihiro,Pais, Godwin C. G.,Nelson, David M.,Song, Yongsheng,Thanassi, Jane A.,Marlor, Christopher W.,Thoma, Christy L.,Cheng, Jijun,Podos, Steven D.,Ou, Yangsi,Deshpande, Milind,Pucci, Michael J.,Buechter, Douglas D.,Bradbury, Barton J.,Wiles, Jason A.. "Isothiazoloquinolones with enhanced antistaphylococcal activities against multidrug-resistant strains: Effects of structural modifications at the 6-, 7-, and 8-positions". . p. 199 - 210. Retrieved 2007/10/03.