Triphenylmethyl Irbesartan

Base Information Edit

Chemical Name:Triphenylmethyl Irbesartan
CAS No.:138402-10-5
Molecular Formula:C44H42N6O
Molecular Weight:670.857
Hs Code.:2933990090
Nikkaji Number:J2.567.719F
Mol file:138402-10-5.mol

Synonyms:Triphenyl irbesartan;Triphenylmethyl Irbesartan;1,3-Diazaspiro[4.4]non-1-en-4-one, 2-butyl-3-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-;2-butyl-3-[[4-[2-(1-trityltetrazol-5-yl)phenyl]phenyl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one;TRITYL IRBESTARTAN;SCHEMBL2209436;BCP12008;MFCD08460099;AKOS015960423;AS-13628;CS-0135692;2-Butyl-3-[2'-(1-trityl-1H-tetrazole-5-yl)-4-biphenylylmethyl]-1,3-diazaspiro[4.4]nona-1-ene-4-one

Suppliers and Price of Triphenylmethyl Irbesartan

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
N-Triphenylmethyl Irbesartan
1g
$ 418.00

TRC
2-Butyl-3-((2''-(2-trityl-2H-tetrazol-5-yl)-[1,1''-biphenyl]-4-yl)methyl)-1,3-diazaspiro[4.4]non-1-en-4-one
10mg
$ 45.00

Matrix Scientific
2-Butyl-3-((2'-(2-trityl-2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1,3-diazaspiro[4.4]non-1-en-4-one 95+%
1g
$ 227.00

Matrix Scientific
2-Butyl-3-((2'-(2-trityl-2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1,3-diazaspiro[4.4]non-1-en-4-one 95+%
5g
$ 672.00

Crysdot
2-Butyl-3-((2'-(2-trityl-2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1,3-diazaspiro[4.4]non-1-en-4-one 97%
5g
$ 314.00

Chemenu
2-Butyl-3-((2''-(2-trityl-2H-tetrazol-5-yl)-[1,1''-biphenyl]-4-yl)methyl)-1,3-diazaspiro[4.4]non-1-en-4-one 95+%
5g
$ 297.00

American Custom Chemicals Corporation
TRITYL IRBESARTAN 95.00%
25G
$ 2292.10

American Custom Chemicals Corporation
TRITYL IRBESARTAN 95.00%
1G
$ 473.55

Ambeed
2-Butyl-3-((2'-(2-trityl-2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1,3-diazaspiro[4.4]non-1-en-4-one 97%
25g
$ 298.00

Ambeed
2-Butyl-3-((2'-(2-trityl-2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1,3-diazaspiro[4.4]non-1-en-4-one 97%
5g
$ 90.00

Total 107 raw suppliers

Chemical Property of Triphenylmethyl Irbesartan Edit

Chemical Property:

Appearance/Colour:White powder
Vapor Pressure:0mmHg at 25°C
Refractive Index:1.662
Boiling Point:834.612 °C at 760 mmHg
PKA:2.60±0.20(Predicted)
Flash Point:458.557 °C
PSA：76.27000
Density:1.201 g/cm³
LogP:8.46450
Storage Temp.:Sealed in dry,Store in freezer, under -20°C
XLogP3:9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:11
Exact Mass:670.34200998
Heavy Atom Count:51
Complexity:1110

Purity/Quality:

99.5% ^*data from raw suppliers

N-Triphenylmethyl Irbesartan ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCC1=NC2(CCCC2)C(=O)N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NN=NN5C(C6=CC=CC=C6)(C7=CC=CC=C7)C8=CC=CC=C8
Uses Irbesartan (I751000) derivative. 2-Butyl-3-((2''-(2-trityl-2H-tetrazol-5-yl)-[1,1''-biphenyl]-4-yl)methyl)-1,3-diazaspiro[4.4]non-1-en-4-one (CAS# 138402-10-5) is a useful building block, especially in the preparation of the antihypertensive drug, irbesartan.

Technology Process of Triphenylmethyl Irbesartan

There total 14 articles about Triphenylmethyl Irbesartan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 731851-41-5
3-[4-bromobenzyl]-2-n-butyl-1,3-diazaspiro[4.4]non-1-en-4-one

: 138402-10-5
trityl irbesartan

Guidance literature:: 2-(N-triphenylmethyl-tetrazol-5-yl)-phenylboronic acid; palladium diacetate; triphenylphosphine; In tetrahydrofuran; 1,2-dimethoxyethane; at 20 ℃; for 0.666667h;

3-[4-bromobenzyl]-2-n-butyl-1,3-diazaspiro[4.4]non-1-en-4-one; With water; potassium carbonate; In tetrahydrofuran; 1,2-dimethoxyethane; at 20 - 80 ℃; for 3.5h; Heating / reflux;