1-Amino-1-cyclopropanecarbonitrile hydrochloride

Base Information

• Chemical Name: 1-Amino-1-cyclopropanecarbonitrile hydrochloride
• CAS No.: 127946-77-4
• Molecular Formula: C4H7ClN2
• Molecular Weight: 118.566
• Hs Code.: 29269090
• Mol file: 127946-77-4.mol

Synonyms:Cyclopropanecarbonitrile,1-amino-, monohydrochloride (9CI);1-Cyanocyclopropanamine hydrochloride;

Chemical Property of 1-Amino-1-cyclopropanecarbonitrile hydrochloride

Chemical Property:

• Appearance/Colour: White powder
• Vapor Pressure: 0.108mmHg at 25°C
• Melting Point: 223 °C
• Boiling Point: 217.6 °C at 760 mmHg
• Flash Point: 85.4 °C
• PSA: 49.81000
• Density: 1.244 at 20℃
• LogP: 1.50358
• Storage Temp.: Store at 0-5°C
• Water Solubility.: Soluble in water

Purity/Quality:

99% ^*data from raw suppliers

1-Amino-1-cyclopropanecarbonitrile hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25-36-43
• Safety Statements: 26-36/37-45

MSDS Files:

Useful:

Technology Process of 1-Amino-1-cyclopropanecarbonitrile hydrochloride

There total 4 articles about 1-Amino-1-cyclopropanecarbonitrile hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-<(Diphenylmethylene)-amino>-1-cyclopropanecarbonitrile (89985-88-6) → 1-amino-1-cyclopropanecarbonitrile hydrochloride (127946-77-4)

Guidance literature:

With hydrogenchloride; In diethyl ether; at 18 ℃; for 15h;

DOI:10.1021/jo00301a013

Reference yield: 97.4%

1-nitro-1-cyclopropanenitrile → 1-amino-1-cyclopropanecarbonitrile hydrochloride (127946-77-4)

Guidance literature:

1-nitro-1-cyclopropanenitrile; With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; Inert atmosphere;

With hydrogenchloride; at 0 ℃; Solvent;

Reference yield: 97.0%

N,N-diphenylsulfonylaminocyclopropyl nitrile → 1-amino-1-cyclopropanecarbonitrile hydrochloride (127946-77-4)

Guidance literature:

With hydrogenchloride; In ethanol; water; at 50 ℃;

upstream raw materials:

1-<(Diphenylmethylene)-amino>-1-cyclopropanecarbonitrile

Downstream raw materials:

N₂-[(1R)-1-(4-bromophenyl)-3-cyclopropyl-1-(trifluoromethyl)prop-2-yn-1-yl]-N₁-(1-cyanocyclopropyl)-3-(methylsulfonyl)-L-alaninamide

tert-butyl (1-cyanocyclopropyl)carbamate

N-[(S)-1-(1-cyanocyclopropylcarbamoyl)-3,3-difluoro-4-phenylbutyl]-6-azaspiro[2.5]octane-6-carboxamide

N₂-((1S)-1-(4-bromophenyl)-2,2,2-trifluoroethyl)-N₁-(1-cyanocyclopropyl)-S-(2,3-difluorobenzyl)-L-cysteinamide

Refernces

• 1、 -. "Preparation method of 1-amino-1-cyclopropanecarbonitrile hydrochloride". Paragraph 0010; 0012; 0014; 0016; 0018; 0020; 0022; 0024. . Retrieved 2018/03/26.
• 2、 -. "DI-FLUORO CONTAINING COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS". Page/Page column 38-39. . Retrieved 2009/10/30.