(R)-(-)-N-(benzyloxycarbonyl)-2-(2'-oxoethyl)proline methyl ester

Base Information Edit

Chemical Name:(R)-(-)-N-(benzyloxycarbonyl)-2-(2'-oxoethyl)proline methyl ester
CAS No.:157662-41-4
Molecular Formula:C₁₆H₁₉NO₅
Molecular Weight:305.331
Hs Code.:
Mol file:157662-41-4.mol

Synonyms:(R)-(-)-N-(benzyloxycarbonyl)-2-(2'-oxoethyl)proline methyl ester

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Chemical Property of (R)-(-)-N-(benzyloxycarbonyl)-2-(2'-oxoethyl)proline methyl ester Edit

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Technology Process of (R)-(-)-N-(benzyloxycarbonyl)-2-(2'-oxoethyl)proline methyl ester

There total 5 articles about (R)-(-)-N-(benzyloxycarbonyl)-2-(2'-oxoethyl)proline methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 157662-40-3
(R)-N-(benzoyloxycarbonyl)-allylproline methyl ester

: 157662-41-4
(R)-(-)-N-(benzyloxycarbonyl)-2-(2'-oxoethyl)proline methyl ester

Guidance literature:: With sodium periodate; osmium(VIII) oxide; In methanol; water; tert-butyl alcohol; for 2h;
DOI:10.1021/jm070895r

Reference yield:

: 121773-05-5
(R)-N-(benzyloxycarbonyl)-2-(2'-propenyl)proline

: 157662-41-4
(R)-(-)-N-(benzyloxycarbonyl)-2-(2'-oxoethyl)proline methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / diethyl ether / 0.5 h

2: 1.) OsO₄, 2.) sodium periodate / 1) methanol, water, t-butyl alcohol, 30 min; 2) methanol, water, t-butyla alcohol, 2.5 h

With sodium periodate; osmium(VIII) oxide; In diethyl ether;
DOI:10.1021/jo960012w

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 157662-41-4
(R)-(-)-N-(benzyloxycarbonyl)-2-(2'-oxoethyl)proline methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 67 percent / Et₃N / acetonitrile; H₂O / 96 h / Ambient temperature

2: 87 percent / diethyl ether / 0.5 h

3: 1.) OsO₄, 2.) sodium periodate / 1) methanol, water, t-butyl alcohol, 30 min; 2) methanol, water, t-butyla alcohol, 2.5 h

With sodium periodate; osmium(VIII) oxide; triethylamine; In diethyl ether; water; acetonitrile;
DOI:10.1021/jo960012w