Metoclopramide

Base Information Edit

Chemical Name:Metoclopramide
CAS No.:364-62-5
Molecular Formula:C14H22ClN3O2
Molecular Weight:299.801
Hs Code.:2924299090
European Community (EC) Number:206-662-9
UNII:L4YEB44I46
DSSTox Substance ID:DTXSID6045169
Nikkaji Number:J2.037K
Wikipedia:Metoclopramide
Wikidata:Q421095
NCI Thesaurus Code:C62046
RXCUI:6915
Pharos Ligand ID:UKN9M7SRKCSB
Metabolomics Workbench ID:43444
ChEMBL ID:CHEMBL86
Mol file:364-62-5.mol

Synonyms:4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide;Cerucal;Dihydrochloride, Metoclopramide;Hydrochloride, Metoclopramide;Maxolon;Metaclopramide;Metoclopramide;Metoclopramide Dihydrochloride;Metoclopramide Hydrochloride;Metoclopramide Monohydrochloride;Metoclopramide Monohydrochloride, Monohydrate;Monohydrochloride, Metoclopramide;Primperan;Reglan;Rimetin

Suppliers and Price of Metoclopramide

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Metoclopramide
1g
$ 65.00

Sigma-Aldrich
Metoclopramide VETRANAL
100mg
$ 112.00

Sigma-Aldrich
Metoclopramide European Pharmacopoeia (EP) Reference Standard
$ 190.00

Sigma-Aldrich
Metoclopramide European Pharmacopoeia (EP) Reference Standard
m1824990
$ 190.00

DC Chemicals
Metoclopramide >98%
1 g
$ 150.00

Crysdot
Metoclopramide 98+%
100mg
$ 98.00

Biorbyt Ltd
Metoclopramide
1 g
$ 397.80

Aronis compounds
4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide
5g
$ 361.00

Arctom
Metoclopramide ≥99%
100g
$ 103.00

Arctom
Metoclopramide ≥99%
10g
$ 20.00

Total 170 raw suppliers

Chemical Property of Metoclopramide Edit

Chemical Property:

Vapor Pressure:3.22E-07mmHg at 25°C
Melting Point:146-148 °C
Refractive Index:1.553
Boiling Point:418.7 °C at 760 mmHg
PKA:pKa 0.42± 0.03;9.71± 0.02(H2O)(Approximate)
Flash Point:207 °C
PSA：67.59000
Density:1.162 g/cm³
LogP:2.97450
Storage Temp.:2-8°C
Solubility.:Practically insoluble in water, sparingly soluble or slightly soluble in ethanol (96 per cent), slightly soluble in methylene chloride
XLogP3:2.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:299.1400546
Heavy Atom Count:20
Complexity:300

Purity/Quality:

99% ^*data from raw suppliers

Metoclopramide ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22-64
Safety Statements: 36/37

MSDS Files:: SDS file from LookChem

Useful:

Drug Classes:Gastrointestinal Agents
Canonical SMILES:CCN(CC)CCNC(=O)C1=CC(=C(C=C1OC)N)Cl
Recent ClinicalTrials:A Pilot Clinical Trial of a New Neuromodulation Device for Acute Attacks of Migraine in Children and Adolescents
Recent EU Clinical Trials:Exploring P-glycoprotein-mediated efflux transport at the blood-brain barrier as a biomarker of drug-resistance in focal epilepsy
Recent NIPH Clinical Trials:Migraine Study at Emergency Department
Uses Metoclopramide is a treatment of choice of post-operative nausea and vomiting (PONV) prophylaxis. antidiabetic
Therapeutic Function Antiemetic

Technology Process of Metoclopramide

There total 13 articles about Metoclopramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%