2-Bromo-6-fluorobenzaldehyde

Base Information

• Chemical Name: 2-Bromo-6-fluorobenzaldehyde
• CAS No.: 360575-28-6
• Molecular Formula: C7H4BrFO
• Molecular Weight: 203.011
• Hs Code.: 29130000
• Mol file: 360575-28-6.mol

Synonyms:2-Brom-6-fluor-benzaldehyd;2-FLUORO-6-BROMOBENZALDEHYDE;6-bromo-2-fluorobenzaldehyde;6-FLUORO-2-BROMOBENZALDEHYDE;2-bromo-6-fluorobenzenecarbaldehyde;2-bromo-6-fluoro-benzaldehyde;

Chemical Property of 2-Bromo-6-fluorobenzaldehyde

Chemical Property:

• Vapor Pressure: 0.073mmHg at 25°C
• Melting Point: 45-48 °C
• Refractive Index: 1.585
• Boiling Point: 228.49 °C at 760 mmHg
• Flash Point: 91.988 °C
• PSA: 17.07000
• Density: 1.671 /cm³
• LogP: 2.40070
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Sensitive.: Light Sensitive
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

98% ^*data from raw suppliers

2-Bromo-6-fluorobenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: It is a important raw material and intermediate used in organic synthesis agrochemical, pharmaceutical and dyestuff field.

Technology Process of 2-Bromo-6-fluorobenzaldehyde

There total 11 articles about 2-Bromo-6-fluorobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-fluorobromobenzene (1073-06-9) + N-methyl-N-phenylformamide (93-61-8) → 2-bromo-6-fluorobenzaldehyde (360575-28-6)

Guidance literature:

3-fluorobromobenzene; With hydrogenchloride; n-butyllithium; diisopropylamine; In tetrahydrofuran; hexanes; at -78 - -70 ℃; for 2.5h;

N-methyl-N-phenylformamide; In tetrahydrofuran; hexanes; at -78 - -70 ℃; for 2h;

Reference yield: 96.0%

N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-bromo-6-fluorobenzaldehyde (360575-28-6)

Guidance literature:

3-fluorobromobenzene; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 - -60 ℃; for 3.5h;

N,N-dimethyl-formamide; In tetrahydrofuran; hexane; at -71 - -70 ℃; for 1h;

With acetic acid; In tetrahydrofuran; hexane; at -15 ℃; for 0.333333h;

Reference yield: 93.0%

Methyl formate (107-31-3) + 3-fluorobromobenzene (1073-06-9) → 2-bromo-6-fluorobenzaldehyde (360575-28-6)

Guidance literature:

3-fluorobromobenzene; With n-butyllithium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

Methyl formate; In tetrahydrofuran; hexane; at 20 ℃; for 0.5h; Inert atmosphere;

upstream raw materials:

3-fluorobromobenzene

N,N-dimethyl-formamide

n-butyllithium

N-methyl-N-phenylformamide

Downstream raw materials:

2-benzyl-4-bromo-2H-indazole

1-benzyl-4-bromoindazole

1-bromo-3-fluoro-2-methyl-benzene

4-bromoindazole

Refernces

• 1、 -. "Dihydroisocoumarin derivative and preparation method and application thereof". Paragraph 0045; 0047-0048. . Retrieved 2022/01/10.
• 2、 Yong, Qiyun,Sun, Bing,Zhang, Fang-Lin. "Palladium-catalyzed ortho-C(sp2)[sbnd]H bromination of benzaldehydes via a monodentate transient directing group strategy". supporting information. . Retrieved 2019/11/03.