3,5-Dichlorobenzylamine

Base Information

• Chemical Name: 3,5-Dichlorobenzylamine
• CAS No.: 39989-43-0
• Molecular Formula: C7H7 Cl2 N
• Molecular Weight: 176.045
• Hs Code.: 29214990
• Mol file: 39989-43-0.mol

Synonyms:Benzylamine,3,5-dichloro- (6CI); (3,5-Dichlorophenyl)methanamine;3,5-Dichlorobenzenemethanamine; 3,5-Dichlorobenzylamine; [(3,5-Dichlorophenyl)methyl]amine

Chemical Property of 3,5-Dichlorobenzylamine

Chemical Property:

• Refractive Index: 1.575
• Boiling Point: 116 ºC (10 mmHg)
• PKA: 8.48±0.10(Predicted)
• Flash Point: 107.3°C
• PSA: 26.02000
• Density: 1.32
• LogP: 3.15240
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Sensitive.: Air Sensitive

Purity/Quality:

99% ^*data from raw suppliers

3,5-Dichlorobenzylamine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,C
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3,5-Dichlorobenzylamine can be used as modulators of 5''-nucleotidase as a chemotherapeutic agent.

Technology Process of 3,5-Dichlorobenzylamine

There total 4 articles about 3,5-Dichlorobenzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C7H5Cl2N → 3,5-dichlorobenzylamine (39989-43-0)

Guidance literature:

With methanol; sodium tetrahydroborate; calcium chloride; at 20 - 30 ℃; for 6h;

Reference yield:

3,5-dichlorobenzaldehyde oxime (93033-57-9) → 3,5-dichlorobenzylamine (39989-43-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 2h; Heating;

DOI:10.1021/jm00375a005

Reference yield:

3,5-dichlorobenzaldehyde (10203-08-4) → 3,5-dichlorobenzylamine (39989-43-0)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonia / ethanol / 3 h / 25 - 30 °C

2: methanol; calcium chloride; sodium tetrahydroborate / 6 h / 20 - 30 °C

With methanol; sodium tetrahydroborate; ammonia; calcium chloride; In ethanol;

upstream raw materials:

3,5-dichlorobenzaldehyde oxime

benzylamine

3,5-dichlorobenzaldehyde

Downstream raw materials:

3-chloro-propionic acid-(3,5-dichloro-benzylamide)

8-hydroxy-5-(3-piperidin-1-yl-prop-1-ynyl)-[1,6]naphthyridine-7-carboxylic acid 3,5-dichloro-benzylamide

N-(3,5-dichlorobenzyl)-2-(5-isoquinolinyl)propanamide

{2'-[3-(3,5-dichloro-benzyl)-1-ethyl-ureidomethyl]-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl}-acetic acid ethyl ester

Refernces

• 1、 Ye, Hebo,Hai, Yu,Ren, Yulong,You, Lei. "Versatile Dynamic Covalent Assemblies for Probing π-Stacking and Chirality Induction from Homotopic Faces". supporting information. p. 3804 - 3809. Retrieved 2017/03/27.