2,4,6-Trimethoxybenzylamine hydrochloride

Base Information

• Chemical Name: 2,4,6-Trimethoxybenzylamine hydrochloride
• CAS No.: 146548-59-6
• Molecular Formula: C10H15 N O3 . Cl H
• Molecular Weight: 233.695
• Mol file: 146548-59-6.mol

Synonyms:Benzenemethanamine,2,4,6-trimethoxy-, hydrochloride (9CI); 2,4,6-Trimethoxybenzylamine hydrochloride

Chemical Property of 2,4,6-Trimethoxybenzylamine hydrochloride

Chemical Property:

• Appearance/Colour: white to light yellow crystal powde
• Vapor Pressure: 0.000544mmHg at 25°C
• Melting Point: 204-207 °C(lit.)
• Refractive Index: 1.515
• Boiling Point: 312°Cat760mmHg
• Flash Point: 151.1°C
• PSA: 53.71000
• Density: 1.087g/cm³
• LogP: 2.67340
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2,4,6-Trimethoxybenzylamine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,4,6-Trimethoxybenzylamine hydrochloride was used in synthesis of 3-(aminomethyl)isoquinoline.

Technology Process of 2,4,6-Trimethoxybenzylamine hydrochloride

There total 1 articles about 2,4,6-Trimethoxybenzylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2,4,6-trimethoxybenzonitrile (2571-54-2) → 2,4,6-trimethoxy benzyl amine hydrochloride (146548-59-6)

Guidance literature:

2,4,6-trimethoxybenzonitrile; With potassium tert-butylate; In tetrahydrofuran; at 70 ℃; for 12h; Glovebox; Inert atmosphere; Sealed tube;

With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; Glovebox; Inert atmosphere; Sealed tube;

With hydrogenchloride; In methanol; diethyl ether; at 20 ℃; for 0.333333h; Inert atmosphere;

DOI:10.1021/acs.inorgchem.9b01377

Reference yield: 100.0%

2-benzyloxycarbonylamino-3-chlorosulfonylpropionic acid benzyl ester (64957-08-0) + 2,4,6-trimethoxy benzyl amine hydrochloride (146548-59-6) → 2-Benzyloxycarbonylamino-3-(2,4,6-trimethoxy-benzylsulfamoyl)-propionic acid benzyl ester

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

Reference yield: 99.0%

5,6-dichloro-pyrimidine-4-carboxylic acid ethyl ester (1097250-57-1) + 2,4,6-trimethoxy benzyl amine hydrochloride (146548-59-6) → C17H20ClN3O5 (1097250-84-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 3h;

upstream raw materials:

2,4,6-trimethoxybenzonitrile

Downstream raw materials:

[(S)-5-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-5-(2,4,6-trimethoxy-benzylcarbamoyl)-pentyl]-carbamic acid benzyl ester

(S)-4-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-4-(2,4,6-trimethoxy-benzylcarbamoyl)-butyric acid benzyl ester

Z-Glu(t-Bu)-Lys(Boc)-NHTmb

(S)-2-Benzyloxycarbonylamino-4-(2,4,6-trimethoxy-benzylsulfamoyl)-butyric acid

Refernces