2-Methoxy-3-methylpyrazine

Base Information

• Chemical Name: 2-Methoxy-3-methylpyrazine
• CAS No.: 2847-30-5
• Molecular Formula: C6H8N2O
• Molecular Weight: 124.142
• Hs Code.: 29339900
• European Community (EC) Number: 220-651-6,269-881-9
• UNII: 04O7CN9Q85
• DSSTox Substance ID: DTXSID80863034
• Nikkaji Number: J100.520K
• Wikidata: Q27247662
• Metabolomics Workbench ID: 45153
• ChEMBL ID: CHEMBL329881
• Mol file: 2847-30-5.mol

Synonyms:2-METHOXY-3-METHYLPYRAZINE;2847-30-5;Pyrazine, 2-methoxy-3-methyl-;2-Methyl-3-methoxypyrazine;2-Methoxy-3-methyl-pyrazine;68378-13-2;2-methoxy-3-methyl pyrazine;3-Methoxy-2-methylpyrazine;(Methoxy)methylpyrazine;Pyrazine, 2-methoxy-3(or 5)-methyl-;UNII-04O7CN9Q85;Pyrazine, 2-methyl-3-methoxy;2-Methoxy-3(or5)-methylpyrazine;04O7CN9Q85;EINECS 220-651-6;EINECS 269-881-9;63378-13-2;almond pyrazine;chocolate pyrazine A;SCHEMBL422296;Pirazina, 2-metoxi-3-metil-;CHEMBL329881;VKJIAEQRKBQLLA-UHFFFAOYSA-;DTXSID80863034;CHEBI:180378;2-Methoxy-3-methylpyrazine, 99%;2 - methoxy - 3 - methylpyrazine;MFCD00006127;AKOS015852303;METHOXY-3-METHYLPYRAZINE, 2-;CS-W016571;2-METHOXY-3-METHYLPYRAZINE,70-90%,BALANCE10-30%2-METHOXY-6-METHYLPYRAZINE;AC-16642;AM100621;AS-31022;FT-0612784;FT-0657329;FT-0689449;M0810;EN300-157679;FEMA NO. 3183, 2-METHYL-3-METHOXY;2-Methoxy-3-methylpyrazine, >=99%, FCC, FG;FEMA NO. 3280, 2-METHYL-3-METHOXY-;A819467;A836123;Q-100359;W-104912;Q27247662;ETHYL2-METHYL-1,5-DIPHENYLPYRROLE-3-CARBOXYLATE

Chemical Property of 2-Methoxy-3-methylpyrazine

Chemical Property:

• Appearance/Colour: Clear colourless liquid
• Vapor Pressure: 3.27mmHg at 25°C
• Refractive Index: n20/D 1.507(lit.)
• Boiling Point: 159.3 °C at 760 mmHg
• PKA: 1.01±0.10(Predicted)
• Flash Point: 55.6 °C
• PSA: 35.01000
• Density: 1.068 g/cm³
• LogP: 0.79360
• Storage Temp.: Flammables area
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 124.063662883
• Heavy Atom Count: 9
• Complexity: 87.1

Purity/Quality:

99%min ^*data from raw suppliers

2-Methoxy-3-methylpyrazine >98.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-37/38-41-10
• Safety Statements: 26-39-16

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC=CN=C1OC

Technology Process of 2-Methoxy-3-methylpyrazine

There total 2 articles about 2-Methoxy-3-methylpyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methoxypyrazine (3149-28-8) + methyl iodide (74-88-4) → 2-methoxy-3-methylpyrazine (2847-30-5)

Guidance literature:

With 2,2,6,6-tetramethylpiperidinyl-lithium; Yield given. Multistep reaction; 1) hexane, THF, -78 deg C, 15 min, 2) -78 deg C -> rt;

DOI:10.1021/jo00297a085

Reference yield:

→ 2-methoxy-3-methylpyrazine (2847-30-5)

Guidance literature:

Verb. I, Na-Methoxid;

DOI:10.1016/S0040-4020(01)93647-6

Reference yield: 6.0%

2-methoxy-3-methylpyrazine (2847-30-5) → 2-methoxy-3-(trinitromethyl)pyrazine + 2-methoxy-5-nitro-3-(trinitromethyl)pyrazine + 3,4-bis(3-methoxypyrazin-2-yl)furoxan + 3-methoxypyrazine-2-carboxylic acid (40155-47-3)

Guidance literature:

With sulfuric acid; nitric acid; at 30 - 45 ℃; for 4h;

DOI:10.1016/j.mencom.2015.05.011

upstream raw materials:

2-methoxypyrazine

methyl iodide

Downstream raw materials:

3-methoxypyrazine-2-carboxylic acid

Refernces