Metoclopramide hydrochloride

Base Information

• Chemical Name: Metoclopramide hydrochloride
• CAS No.: 54143-57-6
• Deprecated CAS: 49625-23-2
• Molecular Formula: C14H22ClN3O2·ClH·H2O
• Molecular Weight: 354.277
• Hs Code.: 2924296000
• European Community (EC) Number: 230-634-5
• NSC Number: 757117,354467
• UNII: 7B1QZY5SWZ
• DSSTox Substance ID: DTXSID10964306
• Wikidata: Q27267998
• NCI Thesaurus Code: C87710
• RXCUI: 267036
• ChEMBL ID: CHEMBL1256771
• Mol file: 54143-57-6.mol

Synonyms:4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide;Cerucal;Dihydrochloride, Metoclopramide;Hydrochloride, Metoclopramide;Maxolon;Metaclopramide;Metoclopramide;Metoclopramide Dihydrochloride;Metoclopramide Hydrochloride;Metoclopramide Monohydrochloride;Metoclopramide Monohydrochloride, Monohydrate;Monohydrochloride, Metoclopramide;Primperan;Reglan;Rimetin

Chemical Property of Metoclopramide hydrochloride

Chemical Property:

• Melting Point: 182.5-184°
• Boiling Point: 504.6 °C at 760 mmHg
• Flash Point: 259 °C
• PSA: 67.59000
• LogP: 3.77650
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive.: Light Sensitive
• Solubility.: Methanol (Slightly), Water (Slightly)
• Water Solubility.: It is very soluble in water, easily soluble in ethyl alcohol, slightly soluble in dichloromethane.
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 7
• Exact Mass: 335.1167324
• Heavy Atom Count: 21
• Complexity: 300

Purity/Quality:

99% ^*data from raw suppliers

Metoclopramide hydrochloride solid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCN(CC)CCNC(=O)C1=CC(=C(C=C1OC)N)Cl.Cl
• Recent ClinicalTrials: PROUD Study - Preventing Opioid Use Disorders
• Recent EU Clinical Trials: A Phase 2b, Randomized, Multi-Center, Double-Blind, Dose-Ranging Study to Assess the Efficacy, Safety and Pharmacokinetics of Intravenous TAK-954 in Critically Ill Patients With Enteral Feeding Intolerance
• Uses: Metoclopramide Hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and biological fluids by chromatography and chemiluminescence techniques. Dopamine receptor antagonist; antiemetic.
• Indications: Metoclopramide (Reglan) stimulates upper GI tract motility and has both central and peripheral actions. Centrally, it is a dopamine antagonist, an action that is important both for its often desirable antiemetic effect and other less desirable effects. Peripherally, it stimulates the release of intrinsic postganglionic stores of acetylcholine and sensitizes the gastric smooth muscle to muscarinic stimulation. The ability of metoclopramide to antagonize the inhibitory neurotransmitter effect of dopamine on the GI tract results in increased gastric contraction and enhanced gastric emptying and small bowel transit.
• Therapeutic Function: Antiemetic
• Clinical Use: Improved gastric emptying will frequently alleviate symptoms in patients with diabetic, postoperative, or idiopathic gastroparesis. Since metoclopramide also can decrease the acid reflux into the esophagus that results from slowed gastric emptying or lower esophageal sphincter pressure, the drug can be used as an adjunct in the treatment of reflux esophagitis.