1-(4-Hydrazinylbenzyl)-1H-1,2,4-triazole

Base Information

• Chemical Name: 1-(4-Hydrazinylbenzyl)-1H-1,2,4-triazole
• CAS No.: 212248-62-9
• Molecular Formula: C₉H₁₁N₅*2ClH
• Molecular Weight: 262.142
• Hs Code.: 2933990090
• European Community (EC) Number: 606-727-5
• UNII: 335U9MFY9M
• Mol file: 212248-62-9.mol

Synonyms:144035-22-3;212248-62-9;1-(4-Hydrazinylbenzyl)-1H-1,2,4-triazole;1-[(4-Hydrazinylphenyl)methyl]-1H-1,2,4-triazole;[4-(1,2,4-triazol-1-ylmethyl)phenyl]hydrazine;1-(4-Hydrazinophenyl)methyl-1,2,4-triazole;1-(4-hydrazinobenzyl)-1H-1,2,4-triazole;335U9MFY9M;1-((4-Hydrazinylphenyl)methyl)-1H-1,2,4-triazole;1H-1,2,4-Triazole, 1-((4-hydrazinylphenyl)methyl)-;1H-1,2,4-Triazole, 1-[(4-hydrazinylphenyl)methyl]-;1H-1,2,4-Triazole, 1-[(4-hydrazinophenyl)methyl]-, dihydrochloride;4-[(1,2,4-Triazol-1-yl)methyl]phenylhydrazine Dihydrochloride;(1H-1-[(4-Hydrazinophenyl)-methyl]-1,2,4-triazole dihydrochloride;UNII-335U9MFY9M;1H-1,2,4-Triazole, 1-[(4-hydrazinophenyl)methyl]-;SCHEMBL4555632;FUJKUTJPEGEMHG-UHFFFAOYSA-N;AKOS006292887;AC-3465;FT-0669259;FT-0719996;4-(1,2,4-triazol-1-ylmethyl)phenylhydrazine;4-(1,2,4-triazol-1-ylmethyl)phenyl hydrazine;D91037;1-[(4-Hydrazinophenyl)methyl]-1,2,4-Triazole;AR-011/42531524;J-007904

Chemical Property of 1-(4-Hydrazinylbenzyl)-1H-1,2,4-triazole

Chemical Property:

• Boiling Point: 479.9 °C at 760 mmHg
• Flash Point: 244.1 °C
• PSA: 68.76000
• Density: 1.33 g/cm3
• LogP: 1.63460
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly, Sonicated), Methanol (Slightly, Sonicated)
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 189.10144537
• Heavy Atom Count: 14
• Complexity: 167

Purity/Quality:

99% ^*data from raw suppliers

1-(4-Hydrazinylbenzyl)-1H-1,2,4-triazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1CN2C=NC=N2)NN
• Uses: 1-(4-Hydrazinylbenzyl)-1H-1,2,4-triazole can be used as an antimigraine drug.

Technology Process of 1-(4-Hydrazinylbenzyl)-1H-1,2,4-triazole

There total 3 articles about 1-(4-Hydrazinylbenzyl)-1H-1,2,4-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(1,2,4-triazol-1-yl-methyl)phenyl-diazonium chloride (1092370-41-6) → (4-[1,2,4]triazol-1-ylmethylphenyl)hydrazine hydrochloride (154748-67-1,212248-62-9)

Guidance literature:

4-(1,2,4-triazol-1-yl-methyl)phenyl-diazonium chloride; With triphenylphosphine; In methanol; diethyl ether; water; at 5 - 20 ℃; for 8h;

With hydrogenchloride; water; In methanol; diethyl ether; for 5h; Heating / reflux;

Reference yield:

4-(1,2,4-triazol-1-ylmethyl)phenylhydrazine (144035-22-3) → (4-[1,2,4]triazol-1-ylmethylphenyl)hydrazine hydrochloride (154748-67-1,212248-62-9)

Guidance literature:

With hydrogenchloride; In water; at 65 ℃; for 1 - 3h;

Reference yield:

4-(1H-1,2,4-triazol-1-ylmethyl)aniline (119192-10-8) → (4-[1,2,4]triazol-1-ylmethylphenyl)hydrazine hydrochloride (154748-67-1,212248-62-9)

Guidance literature:

4-(1H-1,2,4-triazol-1-ylmethyl)aniline; With hydrogenchloride; sodium nitrite; In water; at -10 - -2 ℃; for 1h;

With sodium sulfite; In water; at -15 - -10 ℃; for 0.5h;

With hydrogenchloride; In water; at 25 - 30 ℃; for 2h;

upstream raw materials:

4-(1,2,4-triazol-1-yl-methyl)phenyl-diazonium chloride

4-(1,2,4-triazol-1-ylmethyl)phenylhydrazine

4-(1H-1,2,4-triazol-1-ylmethyl)aniline

Downstream raw materials:

2-<5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl>ethylamine

Refernces

• 1、 -. "PROCESS FOR THE LARGE SCALE PRODUCTION OF RIZATRIPTAN BENZOATE". Page/Page column 5; 9. . Retrieved 2008/06/13.