4-[(4-ethyl)phenyl]-2-chlorothiophene

Base Information

• Chemical Name: 4-[(4-ethyl)phenyl]-2-chlorothiophene
• CAS No.: 120413-98-1
• Molecular Formula: C₁₂H₁₁ClS
• Molecular Weight: 222.738
• Mol file: 120413-98-1.mol

Synonyms:4-[(4-ethyl)phenyl]-2-chlorothiophene

Chemical Property of 4-[(4-ethyl)phenyl]-2-chlorothiophene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[(4-ethyl)phenyl]-2-chlorothiophene

There total 2 articles about 4-[(4-ethyl)phenyl]-2-chlorothiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

3-[(4-ethyl)phenyl]thiophene (119492-72-7) → 4-[(4-ethyl)phenyl]-2-chlorothiophene (120413-98-1) + 2-chloro-3-(p-ethylphenyl)thiophene

Guidance literature:

With sulfuryl dichloride; In tetrachloromethane; for 8h; Heating;

DOI:10.1246/bcsj.67.2187

Reference yield: 66.0%

2,5-diclorothiophene (3172-52-9,173777-89-4) + ethylbenzene (100-41-4,27536-89-6) → 4-[(4-ethyl)phenyl]-2-chlorothiophene (120413-98-1)

Guidance literature:

With aluminium trichloride; In dichloromethane; 5 deg C_., 30 min., than RT, 1 h;

DOI:10.1246/bcsj.61.3779

Reference yield: 96.0%

4-[(4-ethyl)phenyl]-2-chlorothiophene (120413-98-1) → 3-[(4-ethyl)phenyl]thiophene (119492-72-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; at 20 ℃; for 72h;

DOI:10.1016/j.bmcl.2003.11.066

upstream raw materials:

2,5-diclorothiophene

ethylbenzene

3-[(4-ethyl)phenyl]thiophene

Downstream raw materials:

4,4'-bis(p-ethylphenyl)-2,2'-bithienyl

5-chloro-3,4'-bis(p-ethylphenyl)-2,2'-bithienyl

3-[(4-ethyl)phenyl]thiophene

biphenyl

Refernces

• 1、 Sone,Sato,Umetsu,Yoshino,Takahashi. "Synthesis of unsymmetrical 2,3-diaryl- and 2,4-diarylthiophenes starting from 2,5-dichlorothiophene". . p. 2187 - 2194. Retrieved 2007/10/02.