4-Amino-2-bromopyridine

Base Information

• Chemical Name: 4-Amino-2-bromopyridine
• CAS No.: 7598-35-8
• Molecular Formula: C5H5BrN2
• Molecular Weight: 173.012
• Hs Code.: 29333990
• Mol file: 7598-35-8.mol

Synonyms:Pyridine,4-amino-2-bromo- (6CI,7CI,8CI);2-Bromo-4-aminopyridine;2-Bromopyridin-4-amine;2-Bromopyridin-4-ylamine;NSC404690;

Chemical Property of 4-Amino-2-bromopyridine

Chemical Property:

• Appearance/Colour: Light yellow crystal
• Vapor Pressure: 0.000301mmHg at 25°C
• Melting Point: 92-96 °C
• Refractive Index: 1.636
• Boiling Point: 321.3 °C at 760 mmHg
• PKA: 4.89±0.30(Predicted)
• Flash Point: 148.1 °C
• PSA: 38.91000
• Density: 1.71 g/cm³
• LogP: 2.00750
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

99% ^*data from raw suppliers

4-Amino-2-bromopyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, Xi
• Hazard Codes: Xn,Xi
• Statements: 22-37/38-41-36/37/38-20/21/22
• Safety Statements: 26-36/37/39-36/37/38-36-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Amino-2-bromopyridine is used as medical intermediate.

Technology Process of 4-Amino-2-bromopyridine

There total 10 articles about 4-Amino-2-bromopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-bromo-4-nitropyridine N-oxide (52092-43-0) → 2-bromo-4-aminopyridine (7598-35-8)

Guidance literature:

With iron; In acetic acid; at 100 ℃;

DOI:10.3987/COM-07-11170

Reference yield: 97.0%

2-bromo-4-nitropyridine (6945-67-1) → 2-bromo-4-aminopyridine (7598-35-8)

Guidance literature:

With titanium; for 0.25h;

Reference yield: 55.0%

4-aminopyridine (504-24-5) → 2-bromo-4-aminopyridine (7598-35-8) + 4-amino-3,5-dibromopyridine (84539-34-4)

Guidance literature:

With N-Bromosuccinimide; In tetrachloromethane; at 20 ℃; for 48h; Darkness;

DOI:10.1007/s10593-010-0528-8

upstream raw materials:

2,4-dibromopyridine

2-bromo-4-nitropyridine N-oxide

2-bromo-4-nitropyridine

2-bromo-pyridine

Downstream raw materials:

2-bromoisonicotinonitrile

2,4-dibromopyridine

4-Amino-2-ethoxy-pyridin

2,3-dibromopyridin-4-amine

Refernces

• 1、 Garcia-Lago, Ramon,Alonso-Gomez, Jose-Lorenzo,Sicre, Cristina,Cid, Maria-Magdalena. "Synthesis of 2,4-dibromopyridine and 4,4'-dibromo-2,2'-bipyridine. Efficient usage in selective bromine-substitution under palladium-catalysis". . p. 57 - 64. Retrieved 2008/09/20.
• 2、 -. "CYANOPHENYL DERIVATIVES". . . Retrieved 2008/06/13.